中国医科大学学报2026，Vol.55Issue(1)：1-8,8.DOI:10.12007/j.issn.0258-4646.2026.01.001
逆生:完全分化细胞可塑性在再生与肿瘤发生中的双重角色
Paligenosis:the dual roles of fully differentiated cell plasticity in regeneration and tumorigenesis
摘要
Abstract
Paligenos is the process through which fully differentiated,mature cells reversibly revert to a progenitor-like state via endoge-nous programs thereby contributing to the repair of damaged tissues.This process is comprised of three key stages:activation of autophagy by inhibiting mammalian target of rapamycin complex 1(mTORC1)signaling,which leads to degradation differentiation-specific struc-tures;release from the differentiated state and activation of stem cell-related genes(SOX9 and LGR5);restarting the cell cycle to achieve functional proliferation.Among these stages,the inhibition and subsequent reactivation of mTORC1 is the core regulatory mechanism,responsible for coordinating autophagy,metabolic reprogramming,and genomic surveillance.Paligenosis has dual physiological and patho-logical roles.Various cells,including gastric chief cells and pancreatic acinar cells,participate in damage repair through paligenosis,but its abnormal activation can lead to intestinal metaplasia and an increased risk of carcinogenesis.Furthermore,in tumorigenesis,paligenosis drives mutation accumulation,challenging the"cancer stem cell"theoretical framework to enable differentiated cells to directly participate in tumor origin,thereby mediating drug resistance and metastasis via phenotypic plasticity.This study provides insights into the molecular mechanism of paligenosis,its mode of action in tissue repair,and its association with tumorigenesis,thereby revealing its dual roles in health and disease and informing future research.关键词
逆生/自噬/细胞可塑性/哺乳动物雷帕霉素靶蛋白复合物1Key words
paligenosis/autophagy/cell plasticity/mammalian target of rapamycin complex 1分类
医药卫生引用本文复制引用
袁梦,薛帆,王心雨,欧阳成,苗智峰..逆生:完全分化细胞可塑性在再生与肿瘤发生中的双重角色[J].中国医科大学学报,2026,55(1):1-8,8.基金项目
国家自然科学基金(82072724) （82072724）
辽宁省教育厅资助课题(QNZR2020004) （QNZR2020004）
