中医药学报2026，Vol.54Issue(2)：83-87,5.DOI:10.19664/j.cnki.1002-2392.260039
柴胡龙骨牡蛎汤对肝郁气滞证乳腺增生的临床疗效及免疫功能的影响
Clinical Efficacy of Chaihu Longgu Muli Decoction on Hyperplasia of Mammary Glands with Liver Qi Stagnation Pattern and Its Effect on Immune Function
摘要
Abstract
Objective:To explore the clinical effect of Chaihu Longgu Muli Decoction on breast hyperplasia of liver qi stagnation syndrome and its influence on immune function.Methods:A total of 110 patients with mammary hyperplasia with liver-qi stagnation syndrome admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from July 2023 to July 2024 were selected and divided into 2 groups according to treatment methods,with 55 cases each.The control group was treated with conventional Western medicine,and the observation group was treated with conventional Western medicine combined with bupleurum keel and oyster soup.The efficacy,TCM syndrome score,improvement of breast mass,serum neurotransmitter indexes[5-hydroxytryptamine(5-HT),dopamine(DA)],estrogen indexes[estradiol(E2),prolactin(PRL),progesterone(P)],immune function indexes and drug safety were compared between the two groups.Results:Compared with the control group,the observation group had higher efficacy and less adverse reactions(P<0.05).After treatment,the scores of main syndrome,secondary syndrome,mass maximum diameter and visual analogue scale(VAS)were decreased in both groups,and the decrease was more obvious in the observation group(P<0.05).After treatment,the levels of E2,PRL,5-HT and DA were decreased in both groups,the decrease was more obvious in the observation group,the levels of P,CD3+and CD4+/CD8+were increased in both groups,and the increase was more obvious in the observation group(P<0.05).Conclusion:Chaihu Longgu Muli Decoction is used for clinical treatment of mammary hyperplasia of liver qi stagnation syndrome.It can improve clinical symptoms,breast mass and sex hormone levels,regulate serum neurotransmitter and immune function,improve clinical efficacy and drug safety.关键词
乳腺增生症/柴胡龙骨牡蛎汤/肝郁气滞证/性激素/免疫功能/安全性Key words
Breast hyperplasia/Chaihu Longgu Muli Decoction/Liver-qi stagnation syndrome/Sex hormone/Immune function/Safety分类
医药卫生引用本文复制引用
李伟,张琦..柴胡龙骨牡蛎汤对肝郁气滞证乳腺增生的临床疗效及免疫功能的影响[J].中医药学报,2026,54(2):83-87,5.基金项目
"十二五"国家临床重点专科建设项目(财社[2013]239号) （财社[2013]239号）
阜阳市重点研究与开发计划项目临床医学研究转化专项项目(FK20245528) （FK20245528）
阜阳市卫生健康科研项目(FY2024-042) （FY2024-042）
安徽中医药大学2023年度临床科研项目(2023LCTH18) （2023LCTH18）
