现代牧业2025，Vol.9Issue(4)：1-6,6.
赭曲霉毒素A降解菌贝莱斯芽孢杆菌MM35对小鼠的急性毒性试验研究
Study on the acute toxicity of ochratoxin A degrading bacterium Bacillus velezensis MM35 in mice
摘要
Abstract
In this study,Bacillus velezensis MM35(B.velezensis MM35),an Ochratoxin A(OTA)degrading strain with favorable physiological characteristics previously identified in laboratory screening,was selected for investigation.The strain was subjected to acute toxicity tests and acute eye irritation tests.Results demonstrated that following acute exposure to MM35,mice displayed normal behavior and body weight growth,with no abnormalities,deaths,or bacterial translocation observed.Organ analysis revealed no significant pathological changes in macroscopic characterization or microscopic tissue sections when compared to the control group.Furthermore,detection of inflammatory markers showed that MM35 exposure did not cause inflammatory damage to the liver or spleen and exhibited certain anti-inflammatory properties.Acute eye irritation tests indicated that MM35 eye drops caused no mucosal injury.In conclusion,MM35 exhibits high safety,positioning it as a promising candidate for OTA detoxification.This study lays the groundwork for further research into its application in addressing OTA contamination.关键词
贝莱斯芽孢杆菌/赭曲霉毒素A/降解菌/急性攻毒/粘膜刺激Key words
Bacillus velezensis/OTA/degrading bacteria/acute challenge/mucosal stimulation分类
农业科技引用本文复制引用
薛正涛,许凤茹,李昊轩,段子涵,樊俊琪,顾世铂,申依鑫,张乐乐,贾艳艳..赭曲霉毒素A降解菌贝莱斯芽孢杆菌MM35对小鼠的急性毒性试验研究[J].现代牧业,2025,9(4):1-6,6.基金项目
河南省自然科学基金项目(252300421414). （252300421414）
