信阳师范大学学报（自然科学版）2026，Vol.39Issue(1)：79-85,7.DOI:10.3969/j.issn.2097-583X.2026.01.011
基于过渡金属及可见光催化的3,3-二氟-γ-内酰胺合成进展
Progress in transition-metal-and photoredox-catalyzed 3,3-difluoro-γ-lactam synthesis
摘要
Abstract
Introduction of a difluoroalkyl into small organic molecules would improve their bioactivity,which was prevalently used in drug design.In addition,γ-lactam,as one of the most important nitrogen-containing heterocyclic rings,was widely applied in synthetic and medicinal chemistry.Therefore,the development of synthetic strategies for 3,3-difluoro-γ-lactam was a valuable research topic.The methods of transition-metal-and photoredox-catalyzed 3,3-difluoro-γ-lactam synthesis were summarized,the mechanism and limitation of the reaction were discussed,and the future development direction was prospected.关键词
3,3-二氟-γ-内酰胺/自由基/过渡金属催化/可见光催化/环加成Key words
3,3-difluoro-γ-lactam/radical/transition-metal-catalyzed/photoredox-catalyzed/cycloaddition分类
化学化工引用本文复制引用
唐林,贾锋娟,吴太俊,余蕊均..基于过渡金属及可见光催化的3,3-二氟-γ-内酰胺合成进展[J].信阳师范大学学报（自然科学版）,2026,39(1):79-85,7.基金项目
国家自然科学基金项目(21602190) （21602190）
河南省高等学校重点科研项目(23A150022) （23A150022）
