癌变·畸变·突变2026，Vol.38Issue(1)：15-21,7.DOI:10.3969/j.issn.1004-616x.2026.01.003
炎症营养复合指标与Ⅰ型子宫内膜癌预后的相关性分析
Correlation analysis of inflammation-nutrition composite indexes with prognosis of type Ⅰ endometrial cancer
摘要
Abstract
OBJECTIVE:To evaluate relationships between inflammation-nutrition composite indexes and survival prognosis in patients with type Ⅰ endometrial cancer(EC).METHODS:A total of 404 patients with type Ⅰ EC diagnosed by postoperative pathology from January 2010 to May 2022 were included in this study.Complete blood count and biochemical examination results were collected within one week before surgery.Four inflammatory nutritional composite indicators were calculated:systemic inflammatory response index(SIRI),aggregate index of systemic inflammation(AISI),geriatric nutritional risk index(GNRI),and advanced lung cancer inflammatory index(ALI).Clinicopathological data and follow-up data were also collected.The optimal cutoff value was determined using receiver operating characteristic(ROC)curves.Survival curves were plotted using the Kaplan-Meier method.Univariate and multivariate Cox proportional hazards regression models were used to screen for independent prognostic factors of overall survival(OS).RESULTS:The area under the curves for the inflammatory nutritional indicators were ranked as follows:ALI(0.609)>AISI(0.592)>SIRI(0.581)>GNRI(0.556).Univariate Cox regression showed that age≥60 years,lymph node metastasis,FIGO stage(Ⅲ+Ⅳ),carbohydrate antigen 125(CA125)≥35 U/mL,and ALI<64.32 were significantly associated with shorter OS(all P<0.05).Multivariate Cox regression showed that advanced age[HR=2.25,95％CI(1.02,4.96),P=0.044],high FIGO stage[HR=2.80,95％CI(1.27,6.20),P=0.010],and low ALI[HR=0.28,95％CI(0.08,0.96),P=0.042]were independent risk factors for OS,while SIRI,AISI,and GNRI were not significantly associated with OS(P>0.05).CONCLUSION:Among the four inflammatory and nutritional composite indicators,preoperative ALI had the best prognostic ability for type Ⅰ EC,and ALI<64.32 was an independent risk factor for poor prognosis.关键词
炎症营养复合指标/子宫内膜癌/晚期肺癌炎症指数/总生存期/Cox比例风险回归Key words
inflammation-nutrition composite index/endometrial cancer/advanced lung cancer inflammation index/overall survival/Cox proportional hazards regression分类
医药卫生引用本文复制引用
蔡晓彤,谢冰梦,周莉,李仰康,黄裔腾,彭琳..炎症营养复合指标与Ⅰ型子宫内膜癌预后的相关性分析[J].癌变·畸变·突变,2026,38(1):15-21,7.基金项目
汕头市医疗卫生科技计划(240510226499221) （240510226499221）
