癌变·畸变·突变2026，Vol.38Issue(1)：71-74,4.DOI:10.3969/j.issn.1004-616x.2026.01.012
西洋参黄芪组合物的抗疲劳作用研究
Study on anti-fatigue effect from American ginseng and astragalus
王志鹏 1李梅 1李建国 1李建华 1尹晶晶 1刘欢1
作者信息
- 1. 中国辐射防护研究院药物安全性评价中心,中国核工业集团有限公司放射毒理与放射性药物临床前评价重点实验室,药物毒理及放射性药物临床前研究山西省重点实验室,国家原子能机构核技术(放射性药物非临床评价)研发中心,山西 太原 030006
- 折叠
摘要
Abstract
OBJECTIVE:To study synergistic anti-fatigue effect of different doses and combinations of American ginseng and astragalus,and to screen out the dose with significant anti-fatigue effect.METHODS:American ginseng and astragalus were extracted with water and precipitated with alcohol at a ratio of 1:3,and the precipitate was dried to obtain the herbal extract.The extract was administered to mice by gavage at high,medium,and low doses(600,300,and 150 mg/kg,respectively)for 30 days.A blank control group and a positive control group were also set up.The fatigue resistance of animals in different dose groups was judged by lactate clearance rate test,serum urea nitrogen and creatine kinase content after exercise,liver glycogen content,and changes in related indicators in the weighted swimming test.RESULTS:Compared with the blank control group,each test group showed a reduced area under the curve of serum lactate,increased liver glycogen content,reduced serum urea nitrogen and creatine kinase levels after exercise and increased time to exhaustion in the weighted swimming test(P<0.05 or P<0.01).Compared with the positive control group,the area under the curve(AUC)of blood lactate and the liver glycogen content of mice in the high-dose test substance group were decreased(P<0.01).CONCLUSION:The American ginseng and astragalus combination had an anti-fatigue effect on mice,and the high-dose group has a better anti-fatigue effect than the positive control.关键词
西洋参/黄芪/抗疲劳/小鼠Key words
American ginsengt/astragalus/anti-fatigue/mice分类
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王志鹏,李梅,李建国,李建华,尹晶晶,刘欢..西洋参黄芪组合物的抗疲劳作用研究[J].癌变·畸变·突变,2026,38(1):71-74,4.
