结直肠肛门外科2025，Vol.31Issue(6)：542-549,8.DOI:10.19668/j.cnki.issn1674-0491.2025.06.008
PERK、ATF6 mRNA及蛋白表达对腹腔镜结直肠癌根治术后肝转移的预测价值
Predictive value of PERK and ATF6 mRNA and protein expression for liver metastasis after laparoscopic radical resection of colorectal cancer
摘要
Abstract
Objectives To investigate the value of PERK and ATF6 mRNA and protein expression in predicting liver me-tastasis after laparoscopic radical resection of colorectal cancer.Methods A total of 187 patients who underwent laparo-scopic radical resection for colorectal cancer at Chengdu First People's Hospital were enrolled.They were grouped based on whether liver metastasis occurred within two years postoperatively.General data and colorectal cancer tissue expres-sion levels of PERK and ATF6 mRNA and protein were compared between the two groups.The influence and predictive value of PERK and ATF6 mRNA and protein expression on liver metastasis after laparoscopic radical resection of colorec-tal cancer were analyzed.Results By May 2024,5 cases were lost to follow-up,and the data of 182 patients were fi-nally included for analysis,including 44 cases in the liver metastasis group and 138 cases in the non-liver metastasis group.The liver metastasis rate was 24.18%.Significant differences were observed between the two groups in tumor di-ameter,systemic inflammatory response index(SIRI),preoperative carcinoembryonic antigen(CEA)level,tumor differentia-tion,T stage,N stage,and vascular tumor thrombus(P＜0.05).The expression levels of PERK and ATF6 mRNA and pro-tein in colorectal cancer tissues were lower in the liver metastasis group than in the non-metastasis group(P＜0.05).Multivariate Logistic analysis showed that PERK and ATF6 mRNA and protein expression remained associated with liver metastasis after laparoscopic radical resection of colorectal cancer after adjusting for confounding factors(P＜0.05).Re-ceiver operating characteristic(ROC)curve analysis revealed that the combined prediction of PERK and ATF6 mRNA and protein achieved an area under the curve(AUC)of 0.923 for liver metastasis,which was superior to individual predictive values.Conclusion The expression of PERK and ATF6 mRNA and protein in colorectal cancer tissues areare closely re-lated to liver metastasis after laparoscopic radical resection.Their combined application can assist clinicians in identifying high-risk populations and implementing individualized treatment measures.关键词
结直肠癌/肝转移/腹腔镜结直肠癌根治术/PERK/ATF6/脉管瘤栓/SIRIKey words
colorectal cancer/liver metastasis/laparoscopic radical resection of colorectal cancer/PERK/ATF6/vascular tu-mor thrombus/SIRI分类
医药卫生引用本文复制引用
王毅,张聃,游萧..PERK、ATF6 mRNA及蛋白表达对腹腔镜结直肠癌根治术后肝转移的预测价值[J].结直肠肛门外科,2025,31(6):542-549,8.基金项目
2021年四川省医学(青年创新)科研课题项目(S212021) （青年创新）
