动物营养学报2025，Vol.37Issue(12)：8075-8082,8.DOI:10.12418/CJAN2025.657
肠道菌群介导的次级胆汁酸调节奶牛营养代谢病的可能机制
Potential Mechanisms by Which Gut Microbiota-Mediated Secondary Bile Acids Regulate Nutritional Metabolic Diseases in Dairy Cows
摘要
Abstract
Nutritional metabolic diseases in dairy cows,serving as a critical bottleneck constraining the sustain-able development of dairy farming,exhibit pathological mechanisms closely associated with gut microbiota-me-diated secondary bile acid metabolism.Secondary bile acids are metabolic derivatives transformed from primary bile acids through gut microbiota processing,playing pivotal roles in host nutrient metabolism and immune reg-ulation.This review summarizes the biosynthetic pathways of secondary bile acids,delineates the interplay be-tween bovine gastrointestinal microbiota and secondary bile acid metabolism,and specifically focuses on the mechanistic actions of secondary bile acids in modulating key nutritional metabolic disorders including fatty liv-er disease,ketosis,ruminal acidosis and postpartum paralysis,to provide a theoretical basis for nutritional in-tervention strategies of nutritional metabolic diseases in dairy cows.关键词
次级胆汁酸/肠道菌群/奶牛/营养代谢病Key words
secondary bile acids/gut microbiota/dairy cows/nutritional metabolic diseases分类
农业科技引用本文复制引用
王菲菲,毛永霞,乔国洋,郭延生..肠道菌群介导的次级胆汁酸调节奶牛营养代谢病的可能机制[J].动物营养学报,2025,37(12):8075-8082,8.基金项目
国家自然科学基金项目(32360895) （32360895）
宁夏重点研发计划项目(2024BBF02013) （2024BBF02013）
