陆军军医大学学报2026，Vol.48Issue(2)：181-190,10.DOI:10.16016/j.2097-0927.202511017
中国高空腹血糖相关缺血性脑卒中疾病负担评估、趋势预测与重点人群防控策略:基于GBD 2021的公共卫生预警
Assessment of disease burden and trend prediction of ischemic stroke attributable to high fasting plasma glucose in China:prevention and control strategies for key populations—a public health early warning based on GBD 2021
摘要
Abstract
Objective To systematically assess the disease burden of ischemic stroke(IS)attributable to high fasting plasma glucose(HFPG)among Chinese adults aged 25 years and older from 1990 to 2021 based on 2021 Global Burden of Disease(GBD)data,and to analyze population disparities and project trends for 2022 to 2035,providing evidence for prevention and control strategies.Methods Data were extracted from the GBD 2021 database,including age-standardized mortality rate(ASMR),disability-adjusted life years per million(ASDR),and population subgroup data for HFPG-related IS in China from 1990 to 2021.Joinpoint regression model was used to analyze temporal trends,and Bayesian age-period-cohort(BAPC)model was employed to predict future burden changes.Results Overall,both the ASMR and ASDR for HFPG-related IS showed a declining trend from 1990 to 2021 among individuals aged 25 and older in China.However,in 2021,the ASMR(19.76 per 100 000)and ASDR(354.37 per 100 000 person-years)remained significantly higher than the global levels(ASMR=14.69 per 100 000;ASDR=266.36 per 100 000 person-years).The disease burden was higher in males than in females,with an increasing trend among those aged 25 to 44 years and a non-significant decline among those aged 80 years and older.Projections indicated that China's ASMR and ASDR will be in a continuous decline from 2022 to 2035,with a projected rate of decrease exceeding the global average,though absolute levels will still remain higher than the global average.Conclusion Although the overall burden of HFPG-related is among Chinese individuals aged≥25 years has decreased,the prevention and control situation remains severe.Countermeasures It is recommended to enhance blood glucose screening for high-risk populations and standardized primary care management.Precise intervention strategies should be formulated for males,the elderly,and other young high-risk groups.Additionally,it is essential to improve the continuum of stroke treatment,rehabilitation services,and medical insurance coverage,while establishing a monitoring,evaluation,and early warning system to curb the burden of hyperglycemia-related ischemic stroke.关键词
缺血性脑卒中/风险因素/全球疾病负担/死亡率/伤残调整生命年Key words
ischemic stroke/risk factors/global burden of disease/mortality/disability-adjusted life years分类
医药卫生引用本文复制引用
周银娟,王文,魏海萍..中国高空腹血糖相关缺血性脑卒中疾病负担评估、趋势预测与重点人群防控策略:基于GBD 2021的公共卫生预警[J].陆军军医大学学报,2026,48(2):181-190,10.基金项目
国家自然科学基金面上项目(82201441,82460245) （82201441,82460245）
甘肃省自然科学基金(22JR5RA1002) （22JR5RA1002）
兰州大学第二医院"萃英科技创新"应用基础研究计划(CY2022-MS-A01) （CY2022-MS-A01）
兰州大学第二医院本科生萃英科研培训计划(CYXZ2024-09,CYXZPT2025-35) Supported by the General Program of National Natural Science Foundation of China(82201441,82460245),the Natural Science Foundation of Gansu Province(22JR5RA1002),the Project of"Cuiying Science and Technology Innovation"Program for Applied Basic Research Plan of Lanzhou University Second Hospital(CY2022-MS-A01),and the Project of Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital(CYXZ2024-09,CYXZPT2025-35). （CYXZ2024-09,CYXZPT2025-35）
