分子影像学杂志2026，Vol.49Issue(1)：7-14,8.DOI:10.12122/j.issn.1674-4500.2026.01.02
超声心动图冠状动脉Z值与川崎病患儿心率、炎症指标和血液成分指标的相关性分析
Correlation analysis of echocardiographic coronary artery Z-score with heart rate,inflammatory markers,and blood component indices in children with Kawasaki disease
摘要
Abstract
Objective To analyze the correlation between coronary artery Z-scores measured by echocardiography and heart rate,inflammatory indicators,and blood component indices in children with Kawasaki disease.Methods A total of 233 children with Kawasaki disease admitted to Shaanxi Provincial People's Hospital from March 2022 to March 2025 were enrolled as research subjects.Echocardiography was performed to measure the internal diameters of 6 coronary artery segments,including the left main coronary artery(LMCA),left anterior descending artery(LAD),left circumflex artery(LCX),proximal right coronary artery(RCA),middle RCA,and distal RCA.Z-scores for each vessel segment were calculated,and the maximum Z-score was used as the evaluation index for each child.According to the Z-scores,the children were divided into three groups:Dilatation group(2≤Z-score<2.5),Small coronary aneurysm group(2.5≤Z-score<5),and Medium-large coronary aneurysm group(Z-score≥5).General data of children in each group[gender,age,height,weight,body surface area(BSA),heart rate,fever duration]were collected,and the levels of biochemical indicators[platelets(PLT),C-reactive protein(CRP),white blood cell count(WBC),erythrocyte sedimentation rate(ESR),red blood cell count(RBC),neutrophil percentage(NE%),albumin(ALB),hemoglobin(HGB)]were detected.Correlations between general data,biochemical indicators and Z-scores were analyzed,and multiple linear regression analysis was performed to screen for independent risk factors affecting Z-scores.Results Compared with the Dilatation group and Small coronary aneurysm group,the Medium-large coronary aneurysm group had significantly higher levels of PLT,CRP,WBC,ESR,and NE%(P<0.05),and significantly lower levels of RBC,ALB,and HGB(P<0.05).Z-scores were positively correlated with heart rate,PLT,CRP,WBC,ESR,and NE%(P<0.05),and negatively correlated with RBC,ALB,and HGB(P<0.05).Multiple linear regression analysis showed that CRP(β=0.464),ESR(β=0.198),NE%(β=0.163),and ALB(β=-0.103)had a significant impact on Z-scores(P<0.001).Conclusion CRP,ESR,NE%,and ALB have independent predictive effects on coronary artery Z-scores,and can serve as predictive indicators for evaluating the severity and degree of dilation of coronary artery lesions in children with Kawasaki disease.关键词
川崎病/超声心动图/冠状动脉Z值/诊断/炎症/血液成分Key words
Kawasaki disease/echocardiography/coronary artery Z-score/diagnosis/inflammation/blood components引用本文复制引用
严晓华,张泰鸣,高娜,穆志龙,贺望,万萱,孙亚男,马娟..超声心动图冠状动脉Z值与川崎病患儿心率、炎症指标和血液成分指标的相关性分析[J].分子影像学杂志,2026,49(1):7-14,8.基金项目
陕西省中医药管理局科研课题(2021-01-ZZ-014) （2021-01-ZZ-014）
陕西省中西医结合心血管病防治重点实验室开放课题(2022XXG-YB-003) （2022XXG-YB-003）
陕西省人民医院科技人才项目(拔尖人才)(2022BJ-08) （拔尖人才）
