国际神经病学神经外科学杂志2025，Vol.52Issue(6)：87-94,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.06.013
凋亡小体作为靶向递送载体在胶质母细胞瘤诊断及治疗中的研究进展
Research advances in apoptotic bodies as targeted delivery vehicles in diagnosis and treatment of glioblastoma multiforme
摘要
Abstract
Glioblastoma multiforme(GBM)has a high degree of malignancy and a poor prognosis.For some drugs used to treat GBM,the highly restrictive and complex features of the blood-brain barrier(BBB)prevents them from entering the brain.Extracellular vesicles(EVs)are cell-derived nanoscale vesicle structures,among which exosomes and microvesicles have been shown to have high biological barrier permeability.Therefore,EVs have been used as noninvasive drug delivery vehicles for the treatment of GBM.Apoptotic bodies(AB)are a special type of EVs released by apoptotic cells,and compared with microvesicles and exosomes,the preparation of AB is more controllable and convenient.However,the application value of AB has not been fully explored so far.This article reviews the current status of research on the potential of AB as a drug delivery vehicle to overcome the BBB and treat GBM as targeted therapy,with the characteristics of low toxicity,low immunogenicity,and controllability.关键词
胶质母细胞瘤/血脑屏障/凋亡小体/靶向递送Key words
glioblastoma multiforme/blood-brain barrier/apoptotic bodies/targeted delivery分类
医药卫生引用本文复制引用
刘诗雅,董兴丽,赵伯言,吴佳宁,张若天,靳津,张程,赵世光..凋亡小体作为靶向递送载体在胶质母细胞瘤诊断及治疗中的研究进展[J].国际神经病学神经外科学杂志,2025,52(6):87-94,8.基金项目
国家自然科学基金(NO.82272885) （NO.82272885）
深圳市科技计划资助(JCYJ20210324100001004) （JCYJ20210324100001004）
深圳市科技计划资助(JCYJ20230808105205011) （JCYJ20230808105205011）
广东省普通高校重点领域专项项目(2021ZDZX2020). （2021ZDZX2020）
