神经损伤与功能重建2026，Vol.21Issue(1)：24-28,5.DOI:10.16780/j.cnki.sjssgncj.20250195
血脑屏障外周血生物标志物与帕金森病及帕金森病认知障碍相关性研究
Study on the Correlation between Peripheral Blood Biomarkers of Blood-Brain Barrier and Parkinson's Disease as Well as Parkinson's Disease-Related Cognitive Impairment
摘要
Abstract
Parkinson's disease is a degenerative disorder of the central nervous system,often accompanied by a variety of non-motor symptoms.Cognitive dysfunction is a significant non-motor symptom that severely impairs patients' quality of life.However,the pathogenesis of Parkinson's disease with cognitive impairment remains unclear.The disruption of the blood-brain barrier is believed to mediate and participate in the development of Parkinson's disease and Parkinson's disease with cognitive impairment,and it also influences disease progression.S100 calcium-binding protein B,occludin,claudin-5,aquaporin-4,glial fibrillary acidic protein,and matrix metalloproteinase-9 are all biomarkers reflecting blood-brain barrier disruption,and they also play crucial roles in the pathophysiological processes of Parkinson's disease and Parkinson's disease with cognitive impairment.This article will elaborate on the research progress regarding these specific proteins as peripheral biomarkers of blood-brain barrier disruption and their correlation with the development of Parkinson's disease and Parkinson's disease with cognitive impairment.关键词
帕金森病/认知障碍/血脑屏障/外周血/生物标志物Key words
Parkinson's disease/cognitive impairment/blood brain barrier/peripheral blood/biomarker分类
医药卫生引用本文复制引用
谭玉群,孟新玲..血脑屏障外周血生物标志物与帕金森病及帕金森病认知障碍相关性研究[J].神经损伤与功能重建,2026,21(1):24-28,5.基金项目
新疆维吾尔自治区重点研发计划项目(基于帕金森免疫应答紊乱及其干预策略关键技术研究,建立个体化精准诊疗体系,No.2023B03003-2) （基于帕金森免疫应答紊乱及其干预策略关键技术研究,建立个体化精准诊疗体系,No.2023B03003-2）
