医学分子生物学杂志2026，Vol.23Issue(1)：74-78,5.DOI:10.3870/j.issn.1672-8009.2026.01.010
MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制
The Bidirectional Regulatory Mechanism of MAPK Signaling Pathway in Drug Tolerance and Host Interaction of Candida albicans
摘要
Abstract
Candida albicans is a common opportunistic pathogen fungus in humans.The inva-sive infection it causes have a high mortality rate,posing significant challenges for clinical preven-tion and treatment.The graving problem of drug resistance is one of the primary causes for treatment failure,making it urgent to elucidate its drug resistance mechanisms and identify new drug tar-gets.This article reviews the bidirectional regulatory mechanism of the MAPK signaling pathway in Candida albicans drug tolerance and host interaction:On one hand,it reveals how the MAPK sig-naling pathway mediates interactions between Candida albicans and its host,such as through im-mune evasion and inflammatory responses;On the other hand,it elucidates the MAPK-mediated resistance mechanisms in Candida albicans,including cell wall synthesis and remodeling,hyphal formation,oxidative stress,and biofilm formation,along with recent advances in drug re-search.This aims to provide new insights into understanding the pathogenicity and resistance of Can-dida albicans and to offer theoretical support for developing novel antifungal strategies targeting the MAPK pathway.关键词
白念珠菌/MAPK信号通路/致病机制/耐药性Key words
Candida albicans/MAPK signaling pathway/pathogenesis/drug resistance分类
医药卫生引用本文复制引用
郝梓淇,冯文莉,张静,赵冰倩..MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制[J].医学分子生物学杂志,2026,23(1):74-78,5.基金项目
山西省自然科学基金面上项目(No.202403021221324),山西省基础研究计划项目(No.202403021211116),山西省中医药管理局科研课题(No.ZYYA20102023) This work was supported by grants from the General Project of Natural Science Foundation of Shanxi Province(No.202403021221324),Basic Research Plan Project of Shanxi Province(No.202403021211116),Sci-entific Research Project of Shanxi Provincial Administration of Traditional Chinese Medicine(No.ZYYA20102023) （No.202403021221324）
