河南农业大学学报2026，Vol.60Issue(1)：12-22,11.DOI:10.16445/j.cnki.1000-2340.20251217.001
G蛋白偶联受体二聚化检测方法研究进展
Research progress on dimerization detection methods of G protein coupled receptors
摘要
Abstract
This article reviews various methods currently available for detecting G protein-coupled receptor(GPCR)dimerization such as biochemistry,biophysics,and structural biology methods,sys-tematically elaborates on the relevant principles and key points,and deeply analyzes their advantages and limitations.In the future,efforts should be focused on developing more sensitive and non-invasive detection methods,while also exploring the combined use of multiple techniques to facilitate the inves-tigation of the role of GPCR dimers in disease occurrence and development,and to provide new ideas for drug design,and to further explore its application potential in crop pest and pest and disease con-trol and animal husbandry.关键词
G蛋白偶联受体/二聚化/检测方法/二聚体/药物靶标Key words
G protein coupled receptor/dimerization/testing methods/dimer/drug target分类
生物科学引用本文复制引用
汤恒敏,刘俊科..G蛋白偶联受体二聚化检测方法研究进展[J].河南农业大学学报,2026,60(1):12-22,11.基金项目
国家自然科学基金项目(31900555) （31900555）
河南省科技发展计划项目(242102110175) （242102110175）
中国博士后科学基金面上项目(2020M672329) （2020M672329）
