海南医科大学学报2026，Vol.32Issue(1)：54-63,10.DOI:10.13210/j.cnki.jhmu.20250305.003
胚胎染色体非整倍性对着床前胚胎发育的影响
The effects of chromosome aneuploidy on preimplantation embryos' development
摘要
Abstract
Objective:To analyze the morphological and morphokinetic data of euploid embryos and aneuploid embryos in the preimplantation genetic testing(PGT)cycle,the study aims to explore the impact of chromosomal aneuploidy on the development of preimplantation embryos.Methods:A retrospective analysis was conducted on the developmental data of embryos that under-went PGT and were cultured in time-lapse incubators.Statistical methods,including the Mann-Whitney U test and Chi-Square test,were used to analyze the data.Results:A total of 1888 embryos form 487 clinical cycles were included,including euploid em-bryos were 724(38.30%)and aneuploid embryos were 1 164(61.70%).In embryos that had developed to the blastocyst stage,chromosomal aneuploidy had no impact on D1 and D2 embryos,and had moderate effect on D3 embryos,but had significant im-pact on blastocyst stage embryos,manifested as the worse the Gardner score,the lower the euploidy rate.In terms of morphokinet-ic parameters,In the PGT-A group,when the female age was<35 years old,the parameters with statistically significant differ-ences were t3,t4,CC2,t6,t7,t8,tSB,tB,tB-t8,KIDScore and iDAScore between euploid embryos and aneuploid embryos were statistically significant(P<0.05).When the female age was≥35 years old,the parameters with statistically significant dif-ferences were t6,t7,t8,CC3,tSB,tB,tB-tSB,KIDScore and iDAScore.In the PGT-M group,regardless of whether the fe-male was of advanced age or not,only the iDAScore was statistically significant.In the PGT-SR group,when the female age was<35 years old,the parameters with statistically significant differences were tPNf,t6,t7,t8,CC3,tB,KIDScore and iDAS-core.When the female age was≥35 years old,the parameters with statistically significant differences were tPB2 and iDAScore.All three groups showed that euploid embryos developed faster,had better cell division synchrony than aneuploid embryos,also re-ceived higher scores.Single chromosome aneuploidies of chr-3,chr-7,chr-8,chr-10,chr-11,chr-12,chr-13,chr-15,chr-18,chr-20,and chr-21,had not influence on the morphokinetic of embryos in their preimplantation development.Conclusion:Chro-mosome aneuploidy in embryos has an impact on preimplantation embryo development,but not at every stage.Additionally,some single chromosome aneuploidy abnormalities do not affect preimplantation embryo development.关键词
时差培养/染色体非整倍性/胚胎植入前遗传学检测(PGT)/发育动力学/形态学Key words
Time-lapse/Chromosome aneuploidy/Preimplantation genetic testing(PGT)/Morphokinetic/Morphology分类
医药卫生引用本文复制引用
陈志慧,姚宇飞,马燕琳,钟庆妃,张宇,黄元华..胚胎染色体非整倍性对着床前胚胎发育的影响[J].海南医科大学学报,2026,32(1):54-63,10.基金项目
This study was supported by the Hainan Province Major Science and Technology Plan Project(ZDKJ2021037) （ZDKJ2021037）
Jointly funded by the Hainan Provincial Academician Innovation Platform Research Project and the Hainan Provincial Clinical Medical Center Construction Project 海南省重大科技计划项目(ZDKJ2021037) （ZDKJ2021037）
海南省院士创新平台科研项目及海南省省级临床医学中心建设项目 （）
