赣南医科大学学报2025，Vol.45Issue(12)：1152-1160,9.DOI:10.3969/j.issn.2097-7174.2025.12.005
TyG指数、TyG-BMI和TG/HDL-C比值与过渡期生长激素缺乏症儿童心脏病变的相关性研究
Correlation study of TyG Index,TyG-BMI,and TG/HDL-C ratio with cardiac damage in children with transitional growth hormone deficiency
摘要
Abstract
Objective:To investigate the correlation of the triglyceride-glucose(TyG)index,triglyceride-glucose-body mass index(TyG-BMI),and triglyceride to high-density lipoprotein cholesterol(TG/HDL-C)ratio with cardiac damage in children with transitional growth hormone deficiency(TGHD).Methods:A total of 44 patients aged 15-18 years who were treated and followed up at the Department of Endocrinology and Metabolic Genetics of Jiangxi Provincial Children's Hospital between January 2015 and December 2024 were enrolled.Based on the peak growth hormone(GH)levels from the insulin tolerance test(ITT)and arginine stimulation test,they were divided into a growth hormone deficiency(TGHD)group(n=25)and a partial growth hormone deficiency(Partial GHD)group(n=19).Additionally,20 children with Idiopathic short stature(ISS)in the same age range were included as a control group.Baseline general data,serological indicators,and echocardiographic parameters were collected from the three groups.Differences in baseline data,serological indicators,and cardiac parameters among the three groups were compared,and the correlations of the TyG index,TyG-BMI,and TG/HDL-C ratio with cardiac damage were explored.Results:There were significant differences in gender distribution among the three groups(P=0.014),with the proportion of males being higher than females in all groups.Body mass index(BMI)showed significant differences among the three groups(P=0.005),with the BMI in the TGHD group being significantly higher than that in the ISS group(P＜0.05).The TG/HDL-C ratio in the TGHD group was significantly higher than that in both the ISS group and the Partial GHD group(all P＜0.05).The TyG index in the TGHD group was significantly higher than that in both the ISS group and the Partial GHD group(all P＜0.05).The TyG-BMI index in the TGHD group was significantly higher than that in both the ISS group and the Partial GHD group(all P＜0.05).Compared to the ISS group,the TGHD group exhibited a significant increase in both left ventricular mass index(LVMI)and relative wall thickness(RWT)(P＜0.05).Spearman correlation analysis revealed that the TyG index was positively correlated with left ventricular end-diastolic diameter,interventricular septal end-diastolic thickness,left ventricular end-systolic diameter,left ventricular posterior wall end-systolic thickness,and left atrial diameter(r=0.364,0.435,0.444,0.324,0.332;all P＜0.05).The TyG-BMI was positively correlated with interventricular septal end-diastolic thickness,left ventricular end-systolic diameter,left atrial diameter,and relative wall thickness(r=0.478,0.325,0.465,0.339;all P＜0.05).The TG/HDL-C ratio was positively correlated with left ventricular end-diastolic diameter,interventricular septal end-diastolic thickness,left ventricular posterior wall end-diastolic thickness,left ventricular end-systolic diameter,and left ventricular mass index(r=0.356,0.467,0.311,0.375,0.314;all P＜0.05).Cnclusion:There are significant differences in cardiac structure among children with varying degrees of growth hormone deficiency(GHD)during the transition period,and the severity of cardiac damage is closely related to the TyG index,TyG-BMI,and TG/HDL-C ratio.Children with TGHD who have not received recombinant human growth hormone replacement therapy exhibit structural cardiac abnormalities,with multiple indicators suggesting an increased susceptibility to left ventricular hypertrophy.关键词
过渡期生长激素缺乏症/儿童/三酰甘油葡萄糖指数/三酰甘油葡萄糖-体质量指数/心脏病变Key words
Transitional growth hormone deficiency/Children/Triglyceride-glucose index/Triglyceride-glucose-body mass index/Cardiac lesions分类
医药卫生引用本文复制引用
徐庆博,杨利,杨玉,曹兰芳,黄强,林悦琪..TyG指数、TyG-BMI和TG/HDL-C比值与过渡期生长激素缺乏症儿童心脏病变的相关性研究[J].赣南医科大学学报,2025,45(12):1152-1160,9.基金项目
江西省科技厅重点研发计划项目(20203BBG73041) （20203BBG73041）
