海南医科大学学报2026，Vol.32Issue(1)：73-80,8.DOI:10.13210/j.cnki.jhmu.20250715.001
中医药靶向调控线粒体质量控制系统治疗脑缺血再灌注损伤研究进展
Progress of Chinese medicine targeting and regulating mitochondrial quality control system for the treatment of cerebral ischemia/reperfusion injury
摘要
Abstract
Cerebral ischemia-reperfusion injury(CIRI)is defined as secondary pathological damage that may be triggered when blood perfusion is restored to brain tissue after ischemia.Mitochondria are the"energy powerhouse"of the cell,with impor-tant physiological functions such as supplying energy,metabolizing reactive oxygen species,storing calcium,and mediating pro-grammed cell death.Maintaining mitochondrial homeostasis is therefore decisive for the survival and functional recovery of nerve cells.In contrast,the mitochondrial quality control(MQC)can attenuate CIRI-induced mitochondrial structural and functional damage by regulating the processes of mitochondrial dynamics,mitochondrial autophagy,mitochondrial biogenesis,and mitochon-drial translocation.In recent years,TCM therapies have been more widely applied,which can significantly improve CIRI through multiple pathways,targets and levels.Therefore,a review on the mechanism of MQC in CIRI and the research progress of TCM in CIRI by modulating MQC is conducted to provide new ideas and research directions for the treatment of CIRI in the future.关键词
脑缺血再灌注损伤/中医药/线粒体/线粒体质量控制系统/综述Key words
Cerebral ischemia/reperfusion injury/Chinese medicine/Mitochondria/Mitochondrial quality control/Summa-rize分类
医药卫生引用本文复制引用
邢丽萍,李建辉,刘安南,姚明远,宋婧,李虹霖..中医药靶向调控线粒体质量控制系统治疗脑缺血再灌注损伤研究进展[J].海南医科大学学报,2026,32(1):73-80,8.基金项目
This study was supported by the National Natural Science Foundation of China(82105035) （82105035）
Heilongjiang Provincial Natural Science Foundation of China(LH2023H064) 国家自然科学基金(82105035) （LH2023H064）
黑龙江省自然科学基金(LH2020H064) （LH2020H064）
