赣南医科大学学报2025，Vol.45Issue(12)：1167-1174,8.DOI:10.3969/j.issn.2097-7174.2025.12.007
微创技术和再生医学治疗尿道狭窄的进展
Advances in minimally invasive techniques and regenerative medicine for the treatment of urethral strictures
摘要
Abstract
Urethral stricture is a common and complex urological disease,the pathogenesis of which is the fibrosis of the urethral tissue after injury,leading to obstruction of urinary flow and even urinary tract dysfunction.With the development of modern medical technology,treatment methods are becoming more and more diversified.This paper systematically reviews the minimally invasive treatment strategies for urethral strictures and the progress of regenerative medicine,focusing on the indications and efficacy of minimally invasive methods,such as urethral dilatation,drug-coated balloon,urethral internal incision,urethroplasty,bi-directional lumbaroscopy,stenting,and perineal urethrostomy,as well as exploring the potential value of tissue-engineered scaffolds and stem cell therapies in the restoration of the urethra.Tissue engineering technology,by constructing biofunctionalized scaffolds and combining them with seed cells,demonstrates the application prospect of reconstructing urethral function and reducing fibrosis recurrence.Regenerative medicine is providing more precise,minimally invasive,and individualized treatment options for complex urethral strictures,although clinical translation still faces challenges such as material optimization,standardized practice protocols,and long-term efficacy evaluation.The aim of this article is to provide an evidence-based basis for clinical decision-making and to indicate future research directions.关键词
尿道狭窄/治疗/微创治疗/组织工程/干细胞疗法Key words
Urethral stricture/Treatment/Minimally invasive treatment/Tissue engineering/Stem cell therapy分类
医药卫生引用本文复制引用
陈宏明,肖阳,肖日海..微创技术和再生医学治疗尿道狭窄的进展[J].赣南医科大学学报,2025,45(12):1167-1174,8.基金项目
国家自然科学基金项目(82260141) （82260141）
