国际神经病学神经外科学杂志2025，Vol.52Issue(6)：1-8,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.06.001
中国老年人群甘油三酯和高密度脂蛋白胆固醇比值与认知功能减退的关系:一项基于CHARLS数据库的Cox队列研究
Association between triglyceride/high-density lipoprotein cholesterol ratio and cognitive decline in the elderly population in China:A Cox cohort study based on the CHARLS database
聂枫 1唐涌 1谭英 1施晓会 1程钟慧 1邓晓东 1陈一全 1蒋彩云1
作者信息
- 1. 成都市第七人民医院康复医学科,四川 成都 610021
- 折叠
摘要
Abstract
Objective To investigate the association between triglyceride/high-density lipoprotein cholesterol(TG/HDL-C)ratio and cognitive decline in the elderly population in China.Methods A total of 816 participants from the CHARLS cohort were included in this study.The Cox proportional-hazards regression model was used to assess the potential association between TG/HDL-C ratio and cognitive decline.The restricted cubic spline(RCS)curve was used to fit the dose-response relationship between TG/HDL-C ratio and the risk of cognitive decline in the middle-aged and elderly populations.Sensitivity and subgroup analyses were also performed in this study.Results After adjustment for various risk factors,the results showed that TG/HDL-C ratio was significantly associated with the risk of cognitive decline in individuals aged 60 years and above.Using the Q1 group(TG/HDL-C ratio<1.371)as the reference,the hazard ratio(HR)for the Q2 group(TG/HDL-C ratio 1.372-2.184),Q3 group(TG/HDL-C ratio 2.185-3.581),and Q4 group(TG/HDL-C ratio>3.581)were significantly higher than that of the Q1 group in Model 1,Model 2,and Model 3(all P<0.05).Notably,the HR for the Q2 group relative to the Q1 group was the highest among these groups.The RCS regression analysis revealed a non-linear relationship between TG/HDL-C ratio and cognitive decline 1.47(95%CI:1.17-1.86,P=0.001),with a turning point at a ratio of 2.48.Specifically,TG/HDL-C ratio below this threshold was associated with an increased risk of cognitive decline,while the predictive ability of TG/HDL-C ratio weakened when it exceeded this threshold(P=0.66).The sensitivity analysis confirmed the robustness of these findings.In addition,the association between TG/HDL-C ratio and the risk of cognitive decline was stronger in individuals with a lower educational level compared with those with a higher educational level.Conclusions There is a significant non-linear association between TG/HDL-C ratio and cognitive decline in the elderly Chinese population,and the increase in the risk of cognitive decline is associated with a TG/HDL-C ratio below the threshold of 2.48.These findings help to provide effective strategies for the prevention of cognitive impairment in elderly patients.关键词
认知障碍/甘油三酯和高密度脂蛋白胆固醇比值/老年人群/中国Key words
cognitive impairment/triglyceride/high-density lipoprotein cholesterol ratio/elderly population/Chinese分类
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聂枫,唐涌,谭英,施晓会,程钟慧,邓晓东,陈一全,蒋彩云..中国老年人群甘油三酯和高密度脂蛋白胆固醇比值与认知功能减退的关系:一项基于CHARLS数据库的Cox队列研究[J].国际神经病学神经外科学杂志,2025,52(6):1-8,8.
