国际神经病学神经外科学杂志2025，Vol.52Issue(6)：17-24,8.DOI:10.16636/j.cnki.jinn.1673-2642.2025.06.003
脑梗死急性期血清中二肽基肽酶-3和胱天蛋白酶-9表达水平与患者颈动脉粥样硬化的相关性
Correlation of the expression levels of dipeptidyl peptidase-3 and caspase-9 in serum during the acute stage of cerebral infarction with carotid atherosclerosis in patients
摘要
Abstract
Objective To investigate the correlation of the expression levels of dipeptidyl peptidase-3(DPP3)and caspase-9 in serum during the acute stage of cerebral infarction with the severity of carotid atherosclerosis in patients.Methods In this prospective study,212 patients in the acute stage of cerebral infarction who were treated in Xingtai Central Hospital from January 2023 to November 2024 were enrolled as study group,and 212 volunteers who underwent physical examination during the same period of time were enrolled as control group.The expression levels of DPP3 and caspase-9 were compared between the study group and the control group,between the groups with different severities of cerebral infarction,and between the groups with different severities of carotid atherosclerosis.The linear correlation analysis and the Spearman rank correlation analysis were used to investigate the correlation of DPP3 and caspase-9 with inflammatory markers,the severity of carotid atherosclerosis,and the severity of infarction.The risk factors for severe cerebral infarction and unstable carotid plaque were identified by the multivariate Logistic regression analysis,and the diagnostic performance of DPP3 and caspase-9 was assessed.Results There were significant differences in DPP3,caspase-9,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)between the study group and the control group,between the groups with different severities of cerebral infarction,and between the groups with different severities of carotid atherosclerosis(P<0.05).The correlation analysis showed that DPP3 and caspase-9 were positively correlated with TNF-α,CRP,IL-6,and the severity of carotid atherosclerosis and cerebral infarction.The multivariate Logistic regression analysis showed that DPP3,caspase-9,TNF-α,CRP,and IL-6 were risk factors for severe cerebral infarction.Combined measurement of DPP3 and caspase-9 showed a higher sensitivity than DPP3 or caspase-9 used alone in identifying severe cerebral infarction and unstable carotid plaque.Conclusions The expression levels of DPP3 and caspase-9 in serum during the acute stage of cerebral infarction are significantly correlated with carotid atherosclerosis in patients and can thus be used as important indexes for clinical diagnosis.关键词
脑梗死/二肽基肽酶-3/胱天蛋白酶-9/颈动脉粥样硬化Key words
cerebral infarction/dipeptidyl peptidase-3/caspase-9/carotid atherosclerosis分类
医药卫生引用本文复制引用
贺晓燕,范娇娇,李娟,孔咏梅..脑梗死急性期血清中二肽基肽酶-3和胱天蛋白酶-9表达水平与患者颈动脉粥样硬化的相关性[J].国际神经病学神经外科学杂志,2025,52(6):17-24,8.基金项目
邢台市重点研发计划项目(2023ZC087) （2023ZC087）
