湖南中医药大学学报2026，Vol.46Issue(1)：113-119,7.DOI:10.3969/j.issn.1674-070X.2026.01.015
"肠-肾轴"视角下"脾气散精"理论对慢性肾脏病肠道菌群及免疫功能的影响
Gut microbiota and immune function in chronic kidney disease:An interpretation from the"gut-kidney axis"perspective based on the theory of"spleen qi transporting and distributing nutrient essence throughout the whole body"
摘要
Abstract
The development and progression of chronic kidney disease(CKD),especially stages 2-4,are closely associated with gut microbiota dysbiosis,immune-inflammatory activation,and accumulation of metabolic toxins.The"gut-kidney axis"theory provides an important perspective for understanding these pathological mechanism.Based on the modern concept of the"gut-kidney axis"theory,this paper systematically elaborates the core TCM pathogenesis of"loss of splenic transportation,failure of distribution of refined nutrients,and endogenous production of damp-turbidity",and correlates it with CKD-related pathological mechanisms including gut microbiota dysbiosis,reduced short-chain fatty acids,uremic toxin accumulation,and activation of immune-inflammatory pathways.It further proposes that"impaired spleen qi in transporting and distributing nutrient essence throughout the whole body"disrupts"gut-kidney axis"homeostasis,leading to a vicious cycle of"intestinal microecological imbalance-immune barrier impairment-microinflammation-renal injury",thereby driving the onset and progression of CKD.Accordingly,this paper proposes a TCM therapeutic strategy featuring"resolving dampness and strengthening the spleen as the foundation,warming and tonifying kidney yang as the key,and concurrently dissolving phlegm and removing blood stasis",aiming to restore the function of"spleen qi transporting and distributing nutrient essence throughout the whole body",regulate the gut microbiota and immune function via multiple targets,and interrupt the vicious cycle described above.From this innovative integrated perspective combining the"gut-kidney axis"with the Chinese medicine theory of"spleen qi transporting and distributing nutrient essence throughout the whole body",this paper intends to provides new theoretical insights and ideas for Chinese medicine interventions in CKD.关键词
慢性肾脏病/肠-肾轴/肠道菌群/免疫功能/脾气散精Key words
chronic kidney disease/gut-kidney axis/gut microbiota/immune function/spleen qi transporting and dis-tributing nutrient essence throughout the whole body分类
医药卫生引用本文复制引用
王慧淑,吴泽芝,李祥明,吴邦泰,谢少庭.."肠-肾轴"视角下"脾气散精"理论对慢性肾脏病肠道菌群及免疫功能的影响[J].湖南中医药大学学报,2026,46(1):113-119,7.基金项目
广东省卫济医学发展基金会科研基金项目(K-202505-1-27) （K-202505-1-27）
汕头市科技计划医疗卫生项目(240510106499152). （240510106499152）
