感染、炎症、修复2025，Vol.26Issue(6)：408-411,4.DOI:10.3969/j.issn.1672-8521.2025.06.003
肿瘤恶病质终末期伴肺部感染患者的临床特征
Clinical characteristics of terminal-stage cancer cachexia patients with pulmonary infection
摘要
Abstract
Objective To analyze the clinical characteristics and medication patterns in patients with terminal-stage cancer cachexia complicated by pulmonary infection.Methods A retrospective study was conducted on 106 patients with terminal-stage cancer cachexia admitted to the First Medical Center of the Chinese People's Liberation Army General Hospital from January 2009 to May 2025.Based on the presence of pulmonary infection,they were divided into an infection group(n=44)and a control group(n=62).Comparative analysis was performed on various clinical parameters,including causative pathogens,antimicrobial agents used,primary tumor site,nutritional risk assessment at admission,serum white blood cell count,neutrophil percentage(NEUT%),and serum C-reactive protein(CRP)levels.Results The top three most frequently identified pathogens in sputum from the infection group were Enterobacter spp.(33.33%,8/24),Acinetobacter spp.(25.00%,6/24),and Pseudomonas spp.(16.67%,4/24).The top three most commonly used antimicrobial agents in this group were cefoperazone-sulbactam(38.64%,17/44),meropenem(27.27%,12/44),and levofloxacin sodium chloride(25.00%,11/44).The proportion of patients with a primary lung tumor site in the infection group(27.27%,12/44)was significantly higher than that in the control group(8.06%,5/62,χ2=7.052,P<0.01).While no statistically significant difference was observed in the proportion of patients with nutritional risk at admission between the two groups(P>0.05),a trend toward a higher prevalence was observed in the infection group.No significant differences were found in white blood cell count,NEUT%,or CRP levels between the two groups(P>0.05).Conclusions Terminal-stage cancer cachexia patients with a primary lung tumor have a significantly higher probability of developing pulmonary infection.There is also a trend suggesting an increased probability of pulmonary infection in those with nutritional risk at admission.However,elevated serum infection indicators alone are not sufficient to confirm a localized pulmonary infection.关键词
肿瘤恶病质/肺部感染/终末期/临床分析Key words
cancer cachexia/pulmonary infection/terminal stage/clinical analysis引用本文复制引用
冯宇,呼健..肿瘤恶病质终末期伴肺部感染患者的临床特征[J].感染、炎症、修复,2025,26(6):408-411,4.基金项目
国家自然科学基金资助项目(81173178) （81173178）
