军事医学2025，Vol.49Issue(12)：881-889,9.DOI:10.7644/j.issn.1674-9960.2025.12.001
基于脂质组学对高原与平原地区高血压人群血清脂质标志物的研究
Serum lipidomics of hypertensive populations in high-altitude and plain regions
摘要
Abstract
Objective To identify differential lipids in hypertensive subjects from high-altitude and plain areas and characterize their potential roles in hypertension using lipidomics.Methods Matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry(MALDI-TOF/TOF MS)was employed for the analysis of serum samples obtained from hypertensive subjects living in high-altitude and plain areas.Lipid metabolites were profiled,and significantly differential lipid species were identified by matching with reference databases combined with rigorous statistical analysis.Results A total of twenty lipid metabolites were identified as differentially expressed.Compared with hypertensive subjects from the plains,levels of phosphatidylserine,phosphatidylglycerol and phosphatidylcholine were significantly higher among high-altitude subjects,whereas the levels of ceramide phosphocholine and ceramide and phosphatidic acid were notably decreased.Conclusion Sphingolipid metabolism may play a key role in lipid disorders associated with high-altitude hypertension,suggesting that alterations in sphingolipids can potentially contribute to the pathogenesis of this disease.关键词
高原/高血压/脂质代谢/基质辅助激光解吸电离串联飞行时间质谱法Key words
high-altitude/hypertension/lipid metabolism/matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry分类
医药卫生引用本文复制引用
杨帆,朱星昊,王丽华,张宏斌,刘月程..基于脂质组学对高原与平原地区高血压人群血清脂质标志物的研究[J].军事医学,2025,49(12):881-889,9.基金项目
山东省自然科学基金青年项目(ZR2022QH153) （ZR2022QH153）
济南市"新高校20条"资助项目(202228100) （202228100）
基于藏医"五源三因"学说的高原高血压病临床诊治及藏药开发研究(YDZX2022140) （YDZX2022140）
