军事医学2025，Vol.49Issue(12)：898-904,7.DOI:10.7644/j.issn.1674-9960.2025.12.003
嗜碱性粒细胞-TNF轴可能是脓毒症的保护因素
The basophil-TNF axis may be a protector in sepsis
李金霞 1黄烨 2李君辉 3兰诗诗 2张红星3
作者信息
- 1. 安徽医科大学基础医学院,合肥 230032
- 2. 北京蛋白质组研究中心,北京 102206
- 3. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
Abstract
Objective To investigate the causal relationships between 17 blood cell indices and 4 sepsis subtypes.Methods Based on the genome-wide association study summary statistics,two-sample Mendelian randomization(MR)analyses were conducted to assess causality.The multiplicative random-effects inverse-variance weighted(IVW)method served as the primary analytical approach,supplemented by several analyses to verify the results.Mouse models of sepsis established by the cecal ligation and puncture(CLP)were used to assess the impact of the small-molecule inhibitor of tumor necrosis factor(TNF),UCB-9260.Results The MR analysis indicated that the basophil count(BASO#)among blood cell indices was significantly negatively associated with the occurrence of sepsis(OR=0.814,P=1.15×10-4).Previous studies have revealed that basophil-derived TNF can play a protective role during sepsis in mice,and the TNF-/-mice demonstrated a significantly lower survival rate following sepsis induction.Consistent with these findings,systemic inhibition of TNF in mice significantly reduced bacterial clearance in the blood(P=0.0286)and increased the mortality(P=0.0304).Conclusion Basophils could have a beneficial function in sepsis,and the basophil-TNF axis could emerge as a potential target for therapeutic intervention against sepsis.关键词
孟德尔随机化分析/血细胞指标/脓毒症/嗜碱性粒细胞/肿瘤坏死因子Key words
Mendelian randomization analysis/blood cell indices/sepsis/basophil/tumor necrosis factor分类
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李金霞,黄烨,李君辉,兰诗诗,张红星..嗜碱性粒细胞-TNF轴可能是脓毒症的保护因素[J].军事医学,2025,49(12):898-904,7.
