军事医学2025，Vol.49Issue(12)：905-911,7.DOI:10.7644/j.issn.1674-9960.2025.12.004
壳聚糖-二乙烯三胺五乙酸偶联物膜剂对体表铀清除的研究
Roles of films composed of chitosan-diethylenetriaminepentaacetic acid conjugate in nuclide elimination
张淑秀 1陈书慧 2张首国 1杜丽娜1
作者信息
- 1. 军事科学院军事医学研究院,北京 100850
- 2. 山东中医药大学药学院,济南 250355
- 折叠
摘要
Abstract
Objective To study the ability of a decontaminant-a film-based chitosan(CS)and diethylenetriamine-pentaacetic acid(DTPA)conjugate-to remove radionuclides under waterless or low-water conditions.Methods DTPA was covalently conjugated to CS via amide bond formation to yield CS-DTPA,which was structurally characterized by Fourier-transform infrared spectroscopy(FTIR)and other analytical techniques.The tensile strength and elongation at break of the film were measured by a universal testing machine while the efficacy of the film in removing radionuclides was evaluated using inductively coupled plasma mass spectrometry.Results The successful grafting of DTPA onto CS was confirmed via FTIR,nuclear magnetic resonance hydrogen spectroscopy(1H-NMR),and X-Ray diffraction(XRD).Glycerinum was added to obtain the flexible CS-DTPA film with a tensile strength of(14.51±5.83)MPa and an elongation at break of(326.06±38.06)%,suggesting adequate mechanical properties for skin applications.The clearance rate of uranyl acetoxide on the skin exceeded 90%after CS-DTPA treatment.Compared with DTPA aqueous solution,the film significantly reduced systemic absorption of uranyl acetate,as evidenced by lower blood concentrations.Conclusion The CS-DTPA film can effectively remove uranium contamination from the skin and inhibit transdermal absorption,making it applicable to water-restricted settings.关键词
放射性核素/壳聚糖/二乙烯三胺五乙酸/膜剂Key words
radionuclides/chitosan/diethylenetriaminepentaacetic acid/film分类
医药卫生引用本文复制引用
张淑秀,陈书慧,张首国,杜丽娜..壳聚糖-二乙烯三胺五乙酸偶联物膜剂对体表铀清除的研究[J].军事医学,2025,49(12):905-911,7.
