军事医学2025，Vol.49Issue(12)：918-922,5.DOI:10.7644/j.issn.1674-9960.2025.12.006
乳腺癌辅助放疗后急性放射性皮炎发生现状及影响因素分析
Prevalence and determinants of acute radiation dermatitis in breast cancer patients after adjuvant radiotherapy
李佳怡 1丁萃萃 1杨爱玲 1付玉芳 1林林 1白丽晓1
作者信息
- 1. 解放军总医院第五医学中心肿瘤内科,北京 100071
- 折叠
摘要
Abstract
Objective To analyze the incidence of acute radiation dermatitis(ARD)induced by postoperative adjuvant radiotherapy in breast cancer patients during and after radiotherapy,and to explore the contributors to ARD so as to provide data for formulating phased and individualized prevention and management strategies.Methods A convenient sampling method was used to select 98 patients as subjects who had undergone postoperative intensity-modulated radiation therapy(IMRT)for breast cancer between June 2022 and June 2023.According to the grading criteria for Radiation Therapy Oncology Group(RTOG),the occurrence and severity of ARD in patients during radiotherapy(once a week)and within 6 weeks of radiotherapy(once a week)were dynamically evaluated.The clinical data of the patients was collected.Chi-square test was used for univariate analysis,and Logistic regression analysis was conducted to screen independent contributors.Results Among the 98 patients,96 developed ARD above grade 0,with an overall incidence rate of 97.96%.The incidence rate was 74.5%(73/98)during radiotherapy and 23.5%(23/98)after radiotherapy.ARD was likely 3 to 5 weeks into radiotherapy and 2 weeks after radiotherapy.Univariate analysis showed that age and menopause were significantly correlated with the occurrence of ARD(P<0.05).Multivariate Logistic regression analysis suggested that age<60 years old during radiotherapy was an independent risk factor for ARD(OR=0.272,95%CI 0.091-0.816,P=0.020),so was menopause after radiotherapy(OR=3.057,95%CI 1.120-8.344,P=0.029).Conclusion The overall incidence of ARD is high among breast cancer patients after postoperative radiotherapy,and varies by age.Young patients have a higher risk of ARD during radiotherapy while menopausal ones have an increased risk of ARD after radiotherapy.Clinically,phased prevention and control strategies should be implemented for high-risk groups in different periods to reduce the harm of ARD and improve the radiotherapy prognosis of patients.关键词
乳腺癌/放射治疗/放射性皮炎/影响因素Key words
breast cancer/radiation therapy/radiation dermatitis/influence factor分类
医药卫生引用本文复制引用
李佳怡,丁萃萃,杨爱玲,付玉芳,林林,白丽晓..乳腺癌辅助放疗后急性放射性皮炎发生现状及影响因素分析[J].军事医学,2025,49(12):918-922,5.
