军事医学2025，Vol.49Issue(12)：923-928,6.DOI:10.7644/j.issn.1674-9960.2025.12.007
Larifan:一种具有多种生物学活性的双链RNA药物
Larifan:a multi-functional,double-stranded RNA drug
郭馨杰 1靳亲朋 2赵志虎1
作者信息
- 1. 军事科学院军事医学研究院,北京 100071
- 2. 河南师范大学,河南 新乡 453007
- 折叠
摘要
Abstract
Larifan,a double-stranded ribonucleic acid(dsRNA)derived from Escherichia coli cells infected with bacteriophage f2,demonstrates diverse biological activities and is commonly used in antiviral and anti-cancer therapies.dsRNA serves as a crucial pathogen-associated molecular pattern(PAMP)produced by the majority of DNA and RNA viruses during the infection cycle.Recognition of specific PAMPs by various pattern recognition receptors(PRR)on cell membranes triggers innate immune responses.Being a universal PAMP,natural Larifan dsRNA can perform a multitude of functions,such as inducing interferons,working as broad-spectrum antivirals,combating tumors,immunoregulation,and acting as a vaccine adjuvantby initiating cascade immune reactions.Furthermore,Larifan is already widely used in clinical antiviral therapy.This review traces the origin and development of Larifan,summarizes its primary biological activities,identifies potential problems with Larifan therapy,and outlines future priorities of research.关键词
Larifan/双链RNA/广谱抗病毒作用/干扰素诱导物Key words
Larifan/double-stranded RNA/broad-spectrum antivirals/interferon inducer分类
生物科学引用本文复制引用
郭馨杰,靳亲朋,赵志虎..Larifan:一种具有多种生物学活性的双链RNA药物[J].军事医学,2025,49(12):923-928,6.
