军事医学2025，Vol.49Issue(12)：929-934,6.DOI:10.7644/j.issn.1674-9960.2025.12.008
蓖麻毒素解毒剂研究进展
Research progress in ricin antidotes
段小涛 1辛若正 1曹莹 2万洪志 3李玲玉 1王勃1
作者信息
- 1. 军事科学院军事医学研究院,北京 100850
- 2. 解放军总医院京南医疗区永定路门诊部,北京 100853
- 3. 军事科学院军事医学研究院,天津 300050
- 折叠
摘要
Abstract
Ricin is a plant protein toxin and is a type Ⅱ ribosome inactivating protein.Ricin contains two peptide chains,A and B.Chain B has a lectin function and is responsible for identifying cell surface sites while chain A has N-glycosidase activity,which can inactivate ribosomes and produce cytotoxicity.Ricin is simple to prepare and strongly toxic,so it can be used as a biological warfare agent to threaten human safety.So far,no specific antidote has been officially approved for marketing.In this paper,the in vivo transport process,mechanism of ricin and the research progress in antidotes are reviewed,which is expected to provide a reference for subsequent development of ricin-specific antidotes.关键词
蓖麻毒素/核糖体失活蛋白/解毒剂Key words
ricin/ribosome inactivating protein/antidote分类
医药卫生引用本文复制引用
段小涛,辛若正,曹莹,万洪志,李玲玉,王勃..蓖麻毒素解毒剂研究进展[J].军事医学,2025,49(12):929-934,6.
