临床传统医学和药理学（英文）2025，Vol.6Issue(4)：18-28,11.DOI:10.1016/j.ctmp.2025.200250
复方青黛液全结肠灌肠缓解广泛型溃疡性结肠炎炎症的优势探索
The clinical advantage of pan-colonic enema with Compound Qingdai on the remission of extensive ulcerative colitis
摘要
Abstract
Background:Extensive ulcerative colitis(UC)causes diffuse colonic inflammation and is often less responsive to conventional therapies.Topical treatments such as rectal enemas have limited proximal reach,reducing effi-cacy for pan-colonic disease.Transendoscopic enteral tubing(TET)enables repeated,targeted pan-colonic drug delivery and may enhance the therapeutic effect of traditional Chinese medicine(TCM)enemas. Objective:To evaluate the efficacy and safety of TET-assisted pan-colonic retention enema with Compound Qing-dai compared with conventional rectal enema in patients with active,extensive UC over a 14-day observation period. Methods:18 patients with active,extensive UC(November 2018-September 2021)were randomized 1∶1 to a pan-colonic enema group(n=9)or a rectal enema group(n=9).The experimental group received TET enema,and the control group received rectal administration enema.The cut-off point of evaluation was 14 days,observe and compare the clinical intestinal symptoms,disease severity,endoscopic scores,mucosal histopathology scores,laboratory indicators and adverse reactions of the two groups. Results:After 14 days,both groups demonstrated significant improvements in clinical symptoms and modified Mayo scores compared to baseline(P＜0.05),with greater reduction in the pan-colonic group(P＜0.05).The clinical response rates were 100.0％ for the pan-colonic group and 66.7％for the rectal group;remission rates were 44.4％ and 33.3％,respectively.Regarding the Mayo Endoscopic Subscore(MES),endoscopic mucosal im-provement was significant across all intestinal segments in both groups compared to baseline(P＜0.05),with the pan-colonic group exhibiting superior mucosal healing compared to the rectal group(P＜0.05).The mucosal healing rate was 77.78％ in the pan-colonic group versus 22.22％in the rectal group.Ulcerative Colitis Endo-scopic Index of Severity(UCEIS)scores of both distal and proximal colon improved significantly post-treatment in both groups(P＜0.05).Notably,proximal colon improvement was significantly greater in the pan-colonic group(P＜0.001).Histopathological analysis revealed a significant decrease in Geboes scores in both groups after treatment(P＜0.05),with the pan-colonic group showing superior improvement compared to the rectal group(P＜0.05).The blood biochemical indicators,namely Fecal Calprotectin(FC),White Blood Cell(WBC),Platelet count(PLT),Erythrocyte Sedimentation Rate(ESR),C-reactive Protein(CRP),and stool occult blood(OB)score were all decreased after treatment.Moreover,fecal OB score in both groups were significantly de-creased(P＜0.05),while FC score in pan-colonic colon group was significantly decreased compared with before treatment(P＜0.001).Neither group showed significant adverse effects(P＞0.05). Conclusion:TET-assisted pan-colonic retention enema with Compound Qingdai achieves superior clinical,en-doscopic,and histological outcomes compared with conventional rectal enema in extensive UC,offering a more effective drug delivery method for achieving better inflammation relief and provides a new way for the treatment of UC with TCM.关键词
溃疡性结肠炎/全结肠保留灌肠/复方青黛液/广泛型溃疡性结肠炎Key words
Ulcerative colitis/Pan-colonic colon retention enema/Compound Qingdai enema/Extensive ulcerative colitis引用本文复制引用
钦丹萍,黄瑶,方逸雯,郑思慧,李珍,刘姗,张春丽..复方青黛液全结肠灌肠缓解广泛型溃疡性结肠炎炎症的优势探索[J].临床传统医学和药理学（英文）,2025,6(4):18-28,11.基金项目
Traditional Chinese Medicine Key Research Funding Project of Zhe-jiang Province(No.2022ZZ012) （No.2022ZZ012）
Inheritance Studio Project of Famous Traditional Chinese Medicine Expert QIN Dan-ping in Zhejiang Province(No.GZS2020020). （No.GZS2020020）
