检验医学与临床2026，Vol.23Issue(2)：171-176,6.DOI:10.3969/j.issn.1672-9455.2026.02.005
超声联合血清PTPN3、PDK1检测对乳腺癌腋窝淋巴结转移的诊断价值
Diagnostic value of ultrasound combined with serum PTPN3,PDK1 detection for axillary lymph node metastasis in breast cancer
摘要
Abstract
Objective To explore the diagnostic value of ultrasound combined with serum protein tyrosine phosphatase non receptor type 3(PTPN3)and phosphoinositide dependent protein kinase 1(PDK1)detection for axillary lymph node metastasis in breast cancer.Methods A total of 136 patients who underwent breast cancer surgery from June 2022 to June 2024 in the First Affiliated Hospital of Hunan University of Chinese Medicine were selected as the research subjects.Based on the results of histopathological tests,patients with axillary lymph node metastasis of breast cancer were classified as the metastasis group,and those without axil-lary lymph node metastasis of breast cancer were classified as the non-metastasis group.Ultrasonography was performed on all patients.Enzyme-linked immunosorbent assay(ELISA)method was applied to measure the expression levels of serum PTPN3 and PDK1.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum PTPN3 and PDK1 for axillary lymph node metastasis of breast cancer.The diagnostic value of serum PTPN3,PDK1 combined with ultrasound for axillary lymph node metastasis of breast cancer was analyzed by diagnostic test fourfold table.Results There were 76 cases in the metastasis group and 60 cases in the non-metastasis group.Compared with the non-metastasis group,serum PTPN3 and PDK1 levels were significantly elevated in the metastasis group(P<0.05),while the proportions of unclear borders,lymph node maximum diameter≥7 mm,length-to-width ratio<2,internal echo heterogeneity and a-bundant blood flow signals were obviously higher in the metastasis group(P<0.05).The accuracy,sensitivi-ty and specificity of ultrasound combined with serum PTPN3 and PDK1 in diagnosing axillary lymph node metastasis of breast cancer were 88.24%,96.05%and 78.33%respectively.Compared with the individual de-tection of each indicator,the accuracy,negative predictive value and sensitivity of the three-item combined di-agnosis for axillary lymph node metastasis of breast cancer are significantly higher(P<0.05).Conclusion The levels of serum PTPN3 and PDK1 in patients with axillary lymph node metastasis of breast cancer are ob-viously increased.Ultrasound combined with serum PTPN3 and PDK1 exhibits enhanced diagnostic accuracy in identifying metastatic axillary lymph nodes in breast cancer patients,which can provide reference for the clinical diagnosis of axillary lymph node metastasis in breast cancer.关键词
蛋白酪氨酸去磷酸酶3/磷酸肌醇依赖性蛋白激酶-1/超声/乳腺癌/腋窝淋巴结转移Key words
protein tyrosine phosphatase non receptor type 3/phosphoinositide dependent protein kinase 1/ultrasound/breast cancer/axillary lymph node metastasis分类
医药卫生引用本文复制引用
汤欢,李林璐,罗佳,高怡江..超声联合血清PTPN3、PDK1检测对乳腺癌腋窝淋巴结转移的诊断价值[J].检验医学与临床,2026,23(2):171-176,6.基金项目
湖南省教育厅科学研究项目(24B0348). （24B0348）
