摘要
Abstract
Objective To investigate the effect of cytomegalovirus(CMV)infection on systemic inflammatory response and clinical outcome in elderly patients with ulcerative colitis(UC).Methods A case-control study was conducted to analyze the medical records of 588 elderly UC patients who visited Beijing hospitals from January 2020 to April 2024.According to the presence of CMV infection in the intestine,the patients were divided into CMV positive group(194 cases)and CMV negative group(394 cases).The clinical characteristics[clinical symptoms,colonoscopy],hematopoietic index[C-reactive protein(CRP),neutrophil/Lymphocyte ratio(NLR),and systemic inflammatory response index(SIRI)]of the elderly UC patients in the 2 groups were compared.Record and compare the outcomes of two groups of elderly UC patients after two weeks of treatment.Results Compared with the CMV negative group,the CMV positive group had a longer course of disease and more serious disease,with a higher proportion of fever,abdominal pain and body mass loss,and a higher proportion of longitudinal ulcers,deep ulcers and hole-like ulcers in colonoscopy,and the levels of CRP,NLR and SIRI were significantly increased,with statistical significance(P＜0.05).The good outcome rate of the CMV-negative group was 86.29％(340/394),significantly higher than that of the CMV-positive group,which was 69.59％(135/194),with statistical significance(P＜0.05).Conclusions CMV infection aggravates intestinal inflammation in elderly UC patients,and is not conducive to prognosis.关键词
结肠炎,溃疡性/巨细胞病毒感染/预后/复发/老年人Key words
Colitis,ulcerative/Cytomegalovirus infections/Prognosis/Recurrence/Aged
