检验医学与临床2026，Vol.23Issue(2)：198-202,208,6.DOI:10.3969/j.issn.1672-9455.2026.02.009
MRI灌注参数联合血清LRG1、PDCD5对原发性肝癌的临床诊断价值
Clinical diagnostic value of MRI perfusion parameters combined with serum LRG1 and PDCD5 for primary liver cancer
摘要
Abstract
Objective To investigate the clinical diagnostic value of magnetic resonance imaging(MRI)perfusion parameters combined with serum leucine rich α 2 glycoprotein 1(LRG1)and programmed cell death protein 5(PDCD5)for primary liver cancer(PHC).Methods A total of 119 PHC patients admitted to the hospital from May 2022 to May 2024 were selected as the liver cancer group,and 119 patients with benign liver tumors admitted to the hospital during the same period were selected as the benign group.The baseline data of all subjects were collected.The serum levels of LRG1,PDCD5,alpha-fetoprotein(AFP),as well as MRI per-fusion parameters[volume transfer constant(Ktrans),extracellular extravascular volume fraction(Ve),rate constant(Kep)]were compared between the two groups.Multivariate Logistic regression analysis was used to analyze the influencing factors for PHC.The receiver operating characteristic(ROC)curve was drawn to ana-lyze the diagnostic value of MRI perfusion parameters combined with serum LRG1 and PDCD5 for PHC.Re-sults Compared with the benign group,the serum levels of LRG1 and PDCD5 in the liver cancer group were significantly decreased(P<0.05),while the serum AFP level,the proportion of patients with a history of al-cohol consumption,and the Ktrans,Kep and Ve of the lesions were significantly increased(P<0.05).The results of multivariate Logistic regression analysis showed that history of alcohol consumption and increased serum AFP level were risk factors for PHC(P<0.05),while increased serum levels of LRG1 and PDCD5 were pro-tective factors for PHC(P<0.05).The results of ROC curve analysis showed that the areas under the curve(AUCs)of Ktrans,Kep,Ve and serum LRG1 and PDCD5 in the diagnosis of PHC alone were 0.840,0.825,0.842,0.826 and 0.813,respectively.The AUC of the combined diagnosis of PHC by the five indicators was 0.937,with sensitivity of 84.87%and specificity of 91.60%.The AUC of the combined diagnosis of PHC by the five indicators was significantly higher than that of Ktrans(Z=3.317,P=0.001),Kep(Z=3.498,P=0.001),Ve(Z=3.143,P=0.002),as well as serum LRG1(Z=3.603,P<0.001)and PDCD5(Z=4.450,P<0.001)alone.Conclusion The serum levels of LRG1 and PDCD5 in PHC patients are obviously reduced.The combination of MRI perfusion parameters and serum LRG1 and PDCD5 has high diagnostic value for PHC,and it can be applied clinically for auxiliary diagnosis.关键词
原发性肝癌/磁共振成像/富亮氨酸α2糖蛋白1/程序性细胞死亡蛋白5/临床诊断Key words
primary hepatic carcinoma/magnetic resonance imaging/leucine rich alpha-2 glycoprotein-1/programmed cell death protein 5/clinical diagnosis分类
医药卫生引用本文复制引用
张希铮,李勇航,白宏刚,刘义文..MRI灌注参数联合血清LRG1、PDCD5对原发性肝癌的临床诊断价值[J].检验医学与临床,2026,23(2):198-202,208,6.基金项目
湖北省卫生健康科研项目(WJ2021M081). （WJ2021M081）
