检验医学与临床2026，Vol.23Issue(2)：203-208,6.DOI:10.3969/j.issn.1672-9455.2026.02.010
运动激发试验联合FeNO检测对儿童咳嗽变异性哮喘的诊断价值
Diagnostic value of exercise challenge test combined with FeNO detection on children with cough variant asthma
摘要
Abstract
Objective To explore the diagnostic value of exercise challenge test(ECT)combined with frac-tional exhaled nitric oxide(FeNO)detection on children with cough variant asthma(CVA).Methods A ret-rospective analysis was conducted on the clinical data of 132 children with chronic cough who underwent ECT in Beijing Jingmei Group General Hospital from June 2022 to June 2024.The children were divided into the CVA group(n=72)and the non-CVA group(n=60)based on whether CVA occurred.The forced expiratory volume in one second(FEV1)and forced vital capacity(FVC)were measured by pulmonary function tester,and FEV1/FVC ratio was calculated.The FEV1 decline percentage after ECT was recorded.The level of FeNO was measured by Nakuren breath analyzer(Sunvon-CA2122 NO).Multivariate Logistic regression analysis was used to analyze the influencing factors for CVA in children with chronic cough.Receiver operating charac-teristic(ROC)curve was applied to evaluate the diagnostic value of related indicators for CVA.Results Com-parisons of FVC,FEV1 and FEV1/FVC ratio between the two groups showed no statistically significant differ-ences(P>0.05).The FEV1 decline percentage was significantly higher in the CVA group than that in the non-CVA group(P<0.05).The FeNO level in the CVA group was(20.68±5.09)ppb,which was signifi-cantly higher than(13.56±4.17)ppb in the non-CVA group(P<0.05).Multivariate Logistic regression a-nalysis revealed that increased FEV1 decline percentage and elevated FeNO were independent risk factors for CVA in children with chronic cough(P<0.05).ROC curve analysis suggested that the areas under the curves(AUCs)for predicting CVA in children with chronic cough by FEV1 decline percentage,FeNO alone and in combination were 0.758,0.729 and 0.825,respectively,the AUC of the combination of the two indicators was significantly higher than that of each predictor alone(P<0.05).Conclusion Both FeNO level and FEV1 de-cline percentage after ECT have diagnostic value on CVA in children with chronic cough,and the combined ap-plication of the two indicators can enhance the diagnostic efficiency.关键词
咳嗽变异性哮喘/儿童/运动激发试验/呼出气一氧化氮/第1秒用力呼气容积/诊断Key words
cough variant asthma/children/exercise challenge test/fractional exhaled nitric oxide/forced expiratory volume in one second/diagnosis分类
医药卫生引用本文复制引用
焦素敏,谷卉姿,王巍,刘晓灵..运动激发试验联合FeNO检测对儿童咳嗽变异性哮喘的诊断价值[J].检验医学与临床,2026,23(2):203-208,6.基金项目
北京市自然科学基金项目(7202045) （7202045）
北京京煤集团总医院科研自主项目(ZZ2024-50). （ZZ2024-50）
