辽宁中医杂志2026，Vol.53Issue(1)：179-182,后插6,5.DOI:10.13192/j.issn.1000-1719.2026.01.044
桃红四物汤激活AMPK/mTOR信号通路改善大鼠下肢动脉粥样硬化
Taohong Siwu Decoction(桃红四物汤)Activates AMPK/mTOR Signaling Pathway to Improve Atherosclerosis in Lower Limbs of Rats
摘要
Abstract
Objective The study aimed to analyze the effects and mechanisms of Taohong Siwu Decoction(桃红四物汤)on atherosclerotic in rats based on AMPK/mTOR signaling pathway.Methods Sixty clean male SD rats were selected,with 10 as the blank group and the remaining 50 were fed a high-fat diet and subjected to arterial intimal injury to establish an atherosclerosis model.They were divided into control group,Taohong Siwu Decoction low-dose group(L group),Taohong Siwu Decoction medi-um-dose group(M group),and Taohong Siwu Decoction high-dose group(H group)using a random number table method.Herbal intervention began in the 9th week after modeling.The blank and control groups were orally given 3 mL of distilled water daily,while the L,M and H groups were given the corresponding doses of the concentrated solution orally.The drug intervention lasted for 8 weeks.The degree of atherosclerotic plaques in the lower limb arteries of the rats,the AMPK/mTOR signaling pathway and the differential expressions of vascular smooth muscle cell phenotypic transition-related proteins,such as α-smooth muscle actin(α-SMA)and osteopontin(OPN)were observed.Results Compared to that of the blank group,atherosclerosis in the L,M and H groups of rats was significantly formed,with foam cells visible in the intima.The expressions of p-AMPK and OPN were significantly up-regulated in the L,M and H groups,while the expressions of mTOR and α-SMA were significantly down-reg-ulated(P＜0.05).Conclusion Taohong Siwu Decoction can inhibit the proliferation of smooth muscle cells and slow down the progression of atherosclerosis by activating the AMPK/mTOR signaling pathway,reducing the transformation of smooth muscle cell contraction phenotype to synthetic phenotype.关键词
下肢动脉粥样硬化/桃红四物汤/AMPK/mTOR信号通路/血管平滑肌细胞Key words
lower limb atherosclerosis/Taohong Siwu Decoction(桃红四物汤)/AMPK/mTOR signaling pathway/vascular smooth muscle cells分类
医药卫生引用本文复制引用
董巨,李大勇,何家安..桃红四物汤激活AMPK/mTOR信号通路改善大鼠下肢动脉粥样硬化[J].辽宁中医杂志,2026,53(1):179-182,后插6,5.基金项目
国家自然科学基金项目(81173273) （81173273）
辽宁省教育厅自然科学类项目面上项目(LJKMZ20221325) （LJKMZ20221325）
