岭南现代临床外科2025，Vol.25Issue(6)：360-366,7.DOI:10.3969/j.issn.1009-976X.2025.06.003
急性胆囊炎(Grade Ⅱ)腹腔镜手术中应用荧光即时成像技术——吲哚氰绿最佳使用剂量探讨
Exploring the optimal dosage of indocyanine green in real-time fluorescence imaging during lapa-roscopic surgery for acute cholecystitis(Grade Ⅱ)
陈洽铭 1李镇潘 1黄丹娜 1张卓敏 1王利勇 1姚乐钊 1郑重1
作者信息
- 1. 普宁市人民医院普通外科,广东普宁 515300
- 折叠
摘要
Abstract
Objective To investigate the optimal intravenous dosage of indocyanine green(ICG)during laparoscopic cholecystectomy(LC).Methods Eighty patients scheduled for fluorescence-guided laparo-scopic cholecystectomy(LC)in the Department of General Surgery,Puning People's Hospital,from January 2024 to December 2024 were enrolled as research subjects.They were randomly divided into four groups with 20 cases each using the envelope method.Different doses of indocyanine green(ICG)were intravenously injected intraoperatively in each group:0.125 mg,0.25 mg,0.5 mg,and 5 mg.The extra-hepatic bile duct visualization time,visualization rate,and fluorescence intensity of the liver and bile duct were observed in the four groups.Additionally,the fluorescence intensity ratio between the two(bile duct-to-liver ratio,BLR)was analyzed to evaluate the effect of cholangiography.Results The 0.5 mg group exhibited a superior visualization rate,with a statistically significant difference among the four groups(P=0.01).There was no statistically significant difference in the common bile duct visualization time across the four groups(P=0.162).For the stratified analysis of the bile duct-to-liver ratio(BLR),we counted the number of eligible cases with BLR≥1,BLR≥1.5,BLR≥2,and BLR≥2.5,respectively.The results showed that under the above four BLR stratification criteria,the number of eligible cases in the 0.5 mg group was the highest among the four groups,and there were statistically significant overall differences among the four groups(all P<0.05).Conclusion Intravenous injection of 0.5 mg ICG during LC provides optimal fluorescence imaging for the extrahepatic biliary tract.关键词
急性胆囊炎/荧光胆道造影/吲哚菁绿/腹腔镜胆囊切除术Key words
acute cholecystitis/fluorescence cholangiography/indocyanine green/laparoscopic cholecystectomy分类
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陈洽铭,李镇潘,黄丹娜,张卓敏,王利勇,姚乐钊,郑重..急性胆囊炎(Grade Ⅱ)腹腔镜手术中应用荧光即时成像技术——吲哚氰绿最佳使用剂量探讨[J].岭南现代临床外科,2025,25(6):360-366,7.
