岭南现代临床外科2025，Vol.25Issue(6)：395-398,4.DOI:10.3969/j.issn.1009-976X.2025.06.008
乳腺原发性浸润性混合型印戒细胞癌1例
Invasive mixed signet ring cell carcinoma of the breast:a case report and literature review
于淼 1张萌 1王泽 1贾建东1
作者信息
- 1. 天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津 300073
- 折叠
摘要
Abstract
Objective To report a rare case of primary invasive mixed signet ring cell carcinoma(SRCBC)of the breast,and to investigate its clinical characteristics,diagnostic criteria,differential diagnosis,and treatment and prognosis for improve understanding of this rare disease.Methods Clinical data,imaging findings,pathological results(core-needle biopsy and postoperative),and treatment course(right total mastectomy with low axillary lymph node dissection)of an 83-year-old female patient were retrospectively analyzed with a comprehensive literature review.Results The patient presented with a painless right breast mass.Preoperative imaging suggested malignancy(BI-RADS 4C).Both biopsy and postoperative pathology confirmed invasive mixed carcinoma composed predominantly of mucinous carcinoma(90%)and signet ring cell carcinoma(>20%),with a minor component of grade Ⅱ invasive ductal carcinoma(10%).Immunohistochemistry demonstrated strong ER positivity(90%),low PR expression(<5%),Her-2 negativity,and Ki-67(15%),supporting mammary origin(E-Cadherin+,GATA-3+).Axillary lymph nodes showed no metastasis(0/16).Perioperative management integrated Traditional Chinese Medicine(herbal decoction,auricular acupuncture,micro-acupuncture)with conventional therapy(surgery+supportive care).Metastatic disease was excluded through imaging and clinical history,confirming primary mixed SRCBC(T2N0M0).Conclusion This mixed-pathology case exhibited relatively favorable prognosis due to early pathological stage(T2N0M0)and node-negative status.关键词
印戒细胞癌/乳腺肿瘤/病例报告Key words
signet ring cell carcinoma/breast tumors/case reports分类
医药卫生引用本文复制引用
于淼,张萌,王泽,贾建东..乳腺原发性浸润性混合型印戒细胞癌1例[J].岭南现代临床外科,2025,25(6):395-398,4.
