岭南现代临床外科2025，Vol.25Issue(6)：399-409,11.DOI:10.3969/j.issn.1009-976X.2025.06.009
代谢组学在外科精准医学的研究进展
Research Progress of Metabolomics in Surgical Precision Medicine
摘要
Abstract
Metabolomics is an important branch of systems biology,mainly studying the composition and dynamic changes of endogenous small molecules in organisms.Due to its ability to reflect the pheno-type of the body and its rapid response to physiological and pathological changes,it provides an impor-tant strategy for the diagnosis and treatment of the surgical precision medicine.This article briefly describes the core concepts,mainstream methods,standard experimental procedures and quality control principles of metabolomics technology,and focuses on summarizing its main research progress in the fields of tumor and non-tumor surgery,including risk assessment,lesion identification,prognosis monitoring and perioperative management.It also analyzes the challenges that metabolomics technology currently faces in the process of clinical transformation,such as the standardization of samples and da-tabases,the verification of result repeatability,and the complexity of deep integration of multi-omics data.In the future,with the development of nanosensors and artificial intelligence analysis technology,metabolomics technology is expected to promote the transformation of the predictive model of precision medicine in surgery.关键词
代谢组学/外科/精准医学/临床转化Key words
metabolomics/surgery/precision medicine/clinical translation分类
医药卫生引用本文复制引用
岑美凤,潘文锋,王小娟..代谢组学在外科精准医学的研究进展[J].岭南现代临床外科,2025,25(6):399-409,11.基金项目
广东省医学科研基金(A2024289) （A2024289）
