兰州大学学报（医学版）2025，Vol.51Issue(12)：1-5,18,6.DOI:10.13885/j.issn.2097-681X.2025.12.001
干细胞及外泌体
Stem cells and their exosomes:novel therapeutic perspectives in treating lung disease
摘要
Abstract
Respiratory diseases are associated with high morbidity and mortality,posing a significant threat to global public health.Current clinical treatments primarily focus on relieving symptoms or slowing disease progression,but effective curative options yet remain unavailable.In recent years,stem cells and their derived exosomes have demonstrated considerable therapeutic potentials in pulmonary diseases,owing to their immu-nomodulatory,anti-inflammatory,anti-fibrotic and regenerative properties.As is known,stem cells exert their effects mainly through paracrine mechanisms,promoting lung tissue repair and regeneration.Notably,their exosomes,as essential mediators of intercellular communication,can independently deliver bioactive mole-cules and replicate many of the therapeutic effects of their parent cells.This review highlighted recent advanc-es in using stem cells and exosomes to treat pulmonary diseases,particularly focusing on mesenchymal stem cells and their derived exosomes in preclinical and clinical studies.It also outlined current challenges and future directions,providing a reference for the ongoing development and clinical translation of cell-based ther-apies in respiratory medicine.关键词
干细胞/外泌体/肺部疾病/细胞疗法Key words
stem cell/exosome/lung disease/cell therapy分类
医药卫生引用本文复制引用
徐金富,马景阁..干细胞及外泌体[J].兰州大学学报（医学版）,2025,51(12):1-5,18,6.基金项目
国家自然科学基金杰青项目及重点项目(81925001,82330070) （81925001,82330070）
四大慢病重大专项(2024ZD0522400) （2024ZD0522400）
