兰州大学学报（医学版）2025，Vol.51Issue(12)：6-18,13.DOI:10.13885/j.issn.2097-681X.2025.12.002
转座子在免疫系统中的功能研究
Functional roles of transposable elements in the immune system
摘要
Abstract
Transposable elements(TEs)are widely distributed across eukaryotic genomes and serve as pivotal drivers of genomic architecture plasticity,regulators of gene expression and genome evolution.Emerging stud-ies have illuminated their important roles in the immune system.The transcription of TEs may activate innate immune responses,and TEs may also function as cis-regulatory elements involving in immune-related regula-tory networks.This review provided a comprehensive framework for high-throughput sequencing based stud-ies in TEs and human immune relative diseases.We first summarized the bioinformatics tools and multi-omics strategies developed for studying TEs,and then systematically elucidated the multifaceted biological roles of TEs in antiviral immunity,autoimmunity and tumor immunity.Lastly,we discussed the translational potential of TEs in immunotherapy and how cutting-edge multi-omics,deep learning and other advanced technologies could redefine the TEs-centered research.关键词
转座子/内源性逆转录病毒/免疫应答/多组学/生物信息学工具/重复序列/免疫治疗Key words
transposable element/endogenous retrovirus/immune response/multi-omics/bioinformatics tool/immunotherapy/repeat sequence分类
医药卫生引用本文复制引用
黄紫嫣,陈勋..转座子在免疫系统中的功能研究[J].兰州大学学报（医学版）,2025,51(12):6-18,13.基金项目
国家重点研发计划资助项目(2024YFC2309600) （2024YFC2309600）
上海市浦江人才计划(24PJA151) （24PJA151）
