兰州大学学报（医学版）2025，Vol.51Issue(12)：62-69,8.DOI:10.13885/j.issn.2097-681X.2025.12.009
基于网络药理学与分子对接探讨血府逐瘀汤治疗视网膜静脉阻塞的作用机制
Exploration of the mechanism of Xuefuzhuyu decoction in treating retinal vein occlusion based on network pharmacology and molecular docking
摘要
Abstract
Objective To determine the mechanism of Xuefuzhuyu Decoction in treatment of retinal vein occlusion(RVO)by using network pharmacology,and to verify it by molecular docking.Methods Multiple public databases were utilized to find and screen Xuefuzhuyu Decoction active ingredient targets and RVO disease targets,whose common targets were then used as potential therapeutic targets.The network of"tradi-tional Chinese medicine-active ingredient-potential target"was established and analyzed via by topological parameters to screen the main active ingredients of Xuefuzhuyu Decoction.The protein interactions network of common targets of drugs and diseases was constructed,and the core targets identified.The gene ontology function and Kyoto Encyclopedia of Genes and Genomes enrichment of the common targets were analyzed,and molecular docking of the main active ingredients and core targets finally carried out.Results A total of 157 active ingredients were identified in Xuefuzhuyu Decoction,and 144 potential targets of Xuefuzhuyu Decoction for the treatment of RVO determined,and the main enriched pathways included in the interleu-kin-17 and the tumor necrosis factor signaling pathway,etc.The key molecules include quercetin,luteolin,kaempferol,wogonin and naringenin,etc.signal transducers and activators of transcription 3,mitogen-acti-vated protein kinase 3,transcription factor Jun,mitogen-activated protein kinases 1,and tumor protein 53 were the core therapeutic targets of the soup.The five core targets had good binding activities with the main active ingredients.Conclusion Xuefuzhuyu Decoction may act on key targets such as signal transducers and activators of transcription 3 through quercetin and lignans,etc.,and alleviate the adverse effects of oxidative stress injury,endothelial cell injury,atherosclerosis and lipid deposition through the modulation of signaling pathways,such as interleukin-17,so as to treat RVO.关键词
血府逐瘀汤/视网膜静脉阻塞/网络药理学/分子对接技术/氧化应激Key words
Xuefuzhuyu Decoction/retinal vein occlusion/network pharmacology/molecular docking tech-nology/oxidative stress分类
医药卫生引用本文复制引用
李强,苏宝莹,雷迅文..基于网络药理学与分子对接探讨血府逐瘀汤治疗视网膜静脉阻塞的作用机制[J].兰州大学学报（医学版）,2025,51(12):62-69,8.基金项目
甘肃省自然科学基金资助项目(24JRRA307) （24JRRA307）
