寄生虫与医学昆虫学报2025，Vol.32Issue(4)：210-218,9.DOI:10.3969/j.issn.1005-0507.2025.04.003
节肢动物线原体
CANDIDATUS LARISKELLA ARTHROPODARUM,AN INTRA-MITOCHONDRIAL ALPHA-PROTEOBACTERIUM DETECTED IN IXODES PERSULCATUS IN CHINA
摘要
Abstract
Objective Candidatus Lariskella arthropodarum'(CLA)is a novel intracellular alpha-proteobacterium closely related to Candidatus Midichloria mitochondrii'(CMM),notable for its unique ability to invade and destroy mitochondria within host germline cells.CLA has been proposed as a potential pathogen,as it has occasionally been detected in blood samples from both humans and other vertebrates.However,the mechanisms of CLA infection and transmission remain poorly understood.Methods Natural CLA infection in unfed Ixodes persulcatus was investigated using meta-transcriptomic analysis of specimens collected from Zhalantun City,Hulunbuir League,Inner Mongolia Autonomous Region(IMAR),China.Results The top-matching transcript assembly was 21917 base pairs in length and encoded genes including ccmA,mrdA,lon,ppsC,prmC,ileS,gshB,gmk,rpoC,and rpoB,all identical to CLA.These findings were further confirmed by amplification of 16S rRNA fragments(99.72%identity to CLA;GenBank accession number AB906829.1)from the DNA of the same tick specimens.A sex-biased prevalence of CLA was observed in I.persulcatus,with significantly higher infection rates in females(83.05%)compared to nymphs(46.11%)and males(36.47%).Conclusions This suggests differential adaptation of CLA across tick sexes and developmental stages.关键词
节肢动物线原体/内共生菌/全沟硬蜱/中国Key words
Candidatus Lariskella arthropodarum/Midichloriaceae/Ixodes persulcatus/China分类
医药卫生引用本文复制引用
冯浩,刘智通,秦通,孙毅..节肢动物线原体[J].寄生虫与医学昆虫学报,2025,32(4):210-218,9.基金项目
This study was sponsored by National Key Research and Development Program of China(2022YFC2305001)and State Key Program of Infectious Diseases of China(2017ZX10303404) （2022YFC2305001）
