菌物学报2026，Vol.45Issue(1)：154-162,9.DOI:10.13346/j.mycosystema.250283
亚窄孢灵芝中杜松烷型倍半萜及其α-葡萄糖苷酶抑制活性
Cadinane-type sesquiterpenes from Ganoderma subangustisporum and their α-glucosidase inhibitory activities
摘要
Abstract
The chemical constituents of Ganoderma subangustisporum and their α-glucosidase inhibitory activity were investigated.Two cadinane-type sesquiterpenes,17-hydroxy-12-ethoxycarbonyl-α-cadinol(1)and 12-hydroxy-α-cadinol(2),were isolated from the ethyl acetate extract of G.angustisporum mycelial cultures.Their structures were elucidated through high-resolution mass spectrometry,comprehensive nuclear magnetic resonance spectroscopic analysis and quantum chemical calculations.Compound 1 is novel due to the acetylation of its 12-hydroxy group,while compound 2 is reported for the first time from the genus Ganoderma.Both compounds 1 and 2 exhibited α-glucosidase inhibitory activity,with IC50 values of(96.72±3.87)μmol/L and(56.82±4.70)μmol/L,respectively.Molecular docking results indicate that compounds 1 and 2 primarily interact with key amino acid residues in the active site of α-glucosidase through hydrogen bonds.关键词
亚窄孢灵芝/化学成分/杜松烷型倍半萜/α-葡萄糖苷酶抑制活性/分子对接Key words
Ganoderma subangustisporum/chemical constituent/cadinane-type sesquiterpene/α-glucosidase inhibitory activity/molecular docking引用本文复制引用
马世元,王雨曦,魏玉莲,袁海生..亚窄孢灵芝中杜松烷型倍半萜及其α-葡萄糖苷酶抑制活性[J].菌物学报,2026,45(1):154-162,9.基金项目
国家自然科学基金(32100013) （32100013）
辽宁省联合基金项目博士科研启动项目(2023-BSBA-328) （2023-BSBA-328）
中国科学院沈阳应用生态研究所森林生态与保育重点实验室项目(KLFES-2028) This work was supported by the National Natural Science Foundation of China(32100013),the Liaoning Provincial Joint Fund Program-Doctoral Research Initiation Project(2023-BSBA-328),and the Fund of CAS Key Laboratory of Forest Ecology and Silviculture,Institute of Applied Ecology,Chinese Academy of Sciences(KLFES-2028). （KLFES-2028）
