菌物学报2026，Vol.45Issue(1)：163-174,12.DOI:10.13346/j.mycosystema.250204
桦褐孔菌的化学成分及抗过敏活性
Chemical constituents and anti-allergic activities of Inonotus obliquus
摘要
Abstract
Inonotus obliquus is a medicinal and edible fungus traditionally used for treating diabetes,hyperlipidemia,hepatitis,and related disorders.In this study,by use of solvent extraction and chromatographic techniques(reversed-phase silica gel,normal-phase silica gel,and Sephadex LH-20),eight compounds were isolated from I.obliquus.Based on nuclear magnetic resonance spectroscopic data,these compounds were identified as gallic acid(1),syringic acid(2),caffeic acid(3),4-(3,4-dihydroxyphenyl)-3-buten-2-one(4),inotodiol(5),cortinellin(6),lanosterol(7),and peroxide ergosterol(8).Anti-allergic activity assays demonstrated that inotodiol(5)significantly inhibited mast cell degranulation at concentrations of 4.96,9.92,and 15.50 μmol/L,with inhibition rates of 51.03％,30.53％,and 23.07％,respectively,indicating potent anti-allergic efficacy.Notably,inotodiol(5)exhibited unobserved cytotoxicity at concentrations up to 15.50 μmol/L,highlighting its potential as a candidate for novel anti-allergic drug development.关键词
桦褐孔菌/桦褐孔菌醇/羊毛甾醇/抗过敏活性Key words
Inonotus obliquus/inotodiol/lanosterol/anti-allergic activity引用本文复制引用
李海燕,张慧敏,陈烜著,吴峰,陈维广,郑永标..桦褐孔菌的化学成分及抗过敏活性[J].菌物学报,2026,45(1):163-174,12.基金项目
福建省高校产学合作计划(2024N5005) This work was supported by the Fujian Provincial University-Industry Collaboration Program(2024N5005). （2024N5005）
