菌物研究2025，Vol.23Issue(6)：425-436,12.DOI:10.13341/j.jfr.2025.1948
食用菌多糖调节肠道菌群健康效应机制及构效关系研究进展
Mechanisms and Structure-Activity Relationships of Edible Fungal Polysaccharides in the Modulation of Gut Microbiota for Health Promotion
摘要
Abstract
The gut microbiota(GM)is a critical determinant of host health,with its composition and function dictated largely by dietary components.Edible mushroom polysaccharides,as important dietary bioactive compounds,have gained significant research interest due to their broad physiological activities and unique"microbiota-targeting"properties.This review systematically summarizes current understanding of the health-promoting effects of edible mushroom polysaccharides,which act as prebiotics by fostering the proliferation of beneficial bacteria,suppressing the colonization of pathogens,modulating GM diversity,and regulating the production of microbial metabolites including short-chain fatty acids.Furthermore,we discuss the specific mechanisms through which edible mushroom polysaccharides intervene in chronic diseases,such as obesity,metabolic disorders,inflammatory bowel disease,and liver diseases-via GM modulation.This review aims to provide theoretical insights into the crosstalk between edible mushroom polysaccharides and the GM,thereby offering a scientific basis for developing functional foods and nutritional interventions for disease prevention and management.关键词
食用菌多糖/肠道菌群/健康功能/构效关系Key words
edible fungal polysaccharides/gut microbiota/healthy function/structure-activity rela-tionship分类
医药卫生引用本文复制引用
陈爽,孔青,刘利平,冯杰,张劲松,耿洁,刘艳芳..食用菌多糖调节肠道菌群健康效应机制及构效关系研究进展[J].菌物研究,2025,23(6):425-436,12.基金项目
国家食用菌产业技术体系项目(CARS-20),上海市农业科学院卓越团队建设计划项目(2022A-03) （CARS-20）
