农业生物技术学报2026，Vol.34Issue(1)：175-185,11.DOI:10.3969/j.issn.1674-7968.2026.01.015
基因编辑技术在猪抗病育种中的应用研究进展
Research Progress on the Application of Gene-editing Technology in Pig(Sus scrofa)Breeding for Disease Resistance
摘要
Abstract
As the world's largest producer and consumer of pork,the high-quality development of the pig(Sus scrofa)industry in China is directly related to the country's food safety and economic security.In recent years,outbreaks of African swine fever,Porcine reproductive and respiratory syndrome and Porcine epidemic diarrhea have caused significant economic losses to the pig farming industry.Traditional prevention and control methods face challenges such as lagging vaccine development and drug residues.Traditional disease resistant breeding has a long cycle and slow progress,and there is an urgent need to develop safer and more effective breeding technologies.The emerging gene editing technology,with advantages such as high efficiency,precision,and convenience,has shown great potential in agricultural animal breeding,including pigs,in recent years,providing strong technical support for the cultivation of new disease resistant pig breeds.This article systematically reviews the development history of gene editing technology,with a focus on analyzing the research progress of CRISPR/Cas9 and its derivative technologies in pig disease resistant breeding,aiming to provide theoretical basis and technical guidance for gene editing disease resistant pig breeding research.关键词
猪/抗病育种/基因编辑/病毒性疾病Key words
Pig/Disease resistant breeding/Gene editing/Viral diseases分类
农业科技引用本文复制引用
严颖,赵无迪,朱向星,唐冬生..基因编辑技术在猪抗病育种中的应用研究进展[J].农业生物技术学报,2026,34(1):175-185,11.基金项目
国家重点研发计划(2021YFA0805900) （2021YFA0805900）
广东省重点领域研发计划(2022B0202110002) （2022B0202110002）
广东省科技厅重点高端外国专家项目(2024A1313010040) （2024A1313010040）
动物胚胎工程及分子育种湖北省重点实验室开放课题(KLAEMB-2024-03) （KLAEMB-2024-03）
广西畜禽繁育与疾病防控重点实验室开放课题(ABDC-b202401) （ABDC-b202401）
