神经病学与神经康复学杂志2025，Vol.21Issue(6)：498-507,10.DOI:10.12022/jnnr.2025-0127
A型肉毒毒素联合系列石膏固定治疗痉挛型脑性瘫痪精细运动功能的效果评价
Clinical study on fine motor function of upper limbs in spastic cerebral palsy treated with type A botulinum toxin combined with serial plaster casting
摘要
Abstract
Objective:To evaluate the effects of botulinum toxin type A(BTX-A)injection combined with serial plaster casting on fine motor function and upper limb spasticity in children with spastic cerebral palsy(CP). Methods:A total of 119 children with CP were stratified according to clinical subtype and Manual Ability Classification System(MACS)level,and then randomly divided into an experimental group(n=61)and a control group(n=58)using a random number table.The control group received a single BTX-A injection combined with conventional upper limb rehabilitation training and guidance.The experimental group received additional serial plaster casting.Therapeutic effects were assessed using the Fine Motor Function Measure(FMFM)and the Modified Tardieu Scale(MTS),which assessed spasticity using parameter X,before BTX-A injection,at 1 month,and at 3 months after injection. Results:At 1 month after treatment,FMFM scores and MTS parameter X scores significantly improved in both groups(P<0.05),with the experimental group showing superior outcomes compared to the control group(P<0.05).At 3 months,all scores in the experimental group remained improved despite a slight decrease,while in the control group,all indicators except for elbow extension showed no statistically significant difference compared to those at 1 month post-treatment. Conclusion:BTX-A combined with conventional upper limb rehabilitation training can significantly improve upper limb muscle spasticity and large-joint motor function in children with CP.The addition of serial plaster casting helps to further enhance hand function and prolong the therapeutic effect.关键词
痉挛型脑性瘫痪/A型肉毒毒素/精细运动/系列石膏固定/B型超声引导Key words
Spastic cerebral palsy/Botulinum toxin type A/Fine motor function/Serial plaster casting/B-mode ultrasound guidance引用本文复制引用
孙双全,那芳芳,王大海,张红艳,王春艳..A型肉毒毒素联合系列石膏固定治疗痉挛型脑性瘫痪精细运动功能的效果评价[J].神经病学与神经康复学杂志,2025,21(6):498-507,10.基金项目
黑龙江省卫生健康委员会科技计划-省专项资金项目(20222020011008)Science and Technology Program of Heilongjiang Provincial Health Commission-Provincial Special Funding Project(20222020011008) （20222020011008）
