山东中医杂志2026，Vol.45Issue(1)：17-22,6.DOI:10.16295/j.cnki.0257-358x.2026.01.004
从肠道黏膜免疫稳态探讨"脾为之卫"与肿瘤免疫的相关性
Exploration on Correlation between"Spleen Acting as the Protector of the Body"and Tumor Immunity from Perspective of Intestinal Mucosal Immune Homeostasis
摘要
Abstract
The pathogenesis of tumors is very complex.Modern research suggests that their occurrence and development are closely related to the immune function of the body.Regulating the function of the immune system is a key approach of tumor prevention and treatment.Intestinal mucosal immunity is an important component of the immune system,which can affect the prognosis of diseases and intervene in the therapeu-tic effect.Traditional Chinese medicine(TCM)holds that"spleen acting as the protector of the body",which is a highly summarized description of the spleen's defense function through the medium of defensive qi.The immune site of the intestinal mucosa is located in the intestine,and its function belongs to the spleen,which is highly consistent with the theory in TCM that"spleen acting as the protector of the body".The imbalance of intestinal mucosal immune homeostasis is similar to the pathological transformation process of"spleen acting as the protector of the body-the spleen failing to act as the protector of the body",and"the spleen failing to act as the protector of the body"may be the mechanism of tumor occurrence in TCM.This article takes"spleen acting as the protector of the body"as the entry point to explore the correlation and clinical application between the imbalance of intestinal mucosal immune homeostasis in tumors and"the spleen failing to act as the protector of the body",in order to provide a theoretical basis for the prevention and treatment of tumors from the perspective of"treating the spleen and regulating the protector of the body"to restore intestinal mucosal immune homeostasis.关键词
肿瘤/肠道黏膜免疫/脾为之卫/脾失为卫/肿瘤免疫Key words
tumor/intestinal mucosal immunity/spleen acting as the protector of the body/spleen failing to act as the protector of the body/tumor immunity分类
医药卫生引用本文复制引用
原雅敏,戴义宁,李慧杰,李秀荣..从肠道黏膜免疫稳态探讨"脾为之卫"与肿瘤免疫的相关性[J].山东中医杂志,2026,45(1):17-22,6.基金项目
山东省自然科学基金项目(编号:ZR2021LZY029) （编号:ZR2021LZY029）
