国际眼科杂志2026，Vol.26Issue(2)：273-277,5.DOI:10.3980/j.issn.1672-5123.2026.2.15
OCT及OCTA在糖尿病视神经病变的研究进展
Advancements in optical coherence tomography and optical coherence tomography angiography for diabetic optic neuropathy
摘要
Abstract
Diabetic optic neuropathy(DON)is a common yet frequently overlooked complication of diabetes mellitus(DM),characterized by an insidious onset,nonspecific clinical manifestations,and frequent co-occurrence with diabetic retinopathy(DR),which often leads to delayed diagnosis and irreversible optic nerve damage.Optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)provide non-invasive,high-resolution imaging of the retinal layers,choroid,and optic nerve head,enabling detailed visualization of structural and microvascular changes in DON.This review summarizes recent advances in the application of OCT/OCTA for evaluating peripapillary retinal nerve fiber layer(pRNFL)thickness,ganglion cell complex(GCC)integrity and vessel density(VD)in DON,highlighting that microvascular impairment may precede measurable structural loss.Furthermore,the potential of OCT/OCTA in disease staging,treatment monitoring,and its integration with artificial intelligence(AI)for early screening and risk prediction is discussed.By combining structural and hemodynamic metrics,OCT/OCTA holds promise for improving early detection,risk stratification,and precision management of DON,thereby helping to preserve visual function in affected patients.关键词
糖尿病视神经病变/糖尿病视网膜病变/视盘/微循环/光学相干断层扫描(OCT)/光学相干断层扫描血管成像(OCTA)Key words
diabetic optic neuropathy/diabetic retinopathy/optic disc/microcirculation/optical coherence tomography(OCT)/optical coherence tomography angiography(OCTA)引用本文复制引用
许一帆,李乐,魏菁..OCT及OCTA在糖尿病视神经病变的研究进展[J].国际眼科杂志,2026,26(2):273-277,5.基金项目
河南省研究生教育改革与质量提升工程项目(No.YJS2025AL51) Reform and Quality Enhancement Project of Postgraduate Education of Henan Province(No.YJS2025AL51) （No.YJS2025AL51）
