四川师范大学学报（自然科学版）2026，Vol.49Issue(2)：200-207,8.DOI:10.3969/j.issn.1001-8395.2026.02.005
后叶加压素对焦虑的调节作用及其机制
Regulatory Effects and Mechanisms of Vasopressin on Anxiety
摘要
Abstract
The prevalence of anxiety disorders is rising,and the efficacy of existing treatments is limited.Arginine vasopressin(AVP),a neuropeptide,plays a crucial role in regulating emotions and social behaviors,particularly in the onset and modulation of anxiety,where it exhibits a complex bidirectional influence.This review explores the biological characteristics of A VP and its functions within the central nervous system,focusing on how A VP exerts bidirectional regulation on anxiety by modulating the hypothalamic-pitui-tary-adrenal(HPA)axis and influencing key neural circuits,such as the amygdala.Additionally,it summarizes the impact of different A VP sources,gender differences,social environment,and genetic factors on the relationship between A VP and anxiety.Research indi-cates that maintaining moderate A VP levels is essential for emotional balance,as excessive or insufficient A VP may exacerbate anxiety.Understanding the bidirectional mechanisms of A VP in anxiety regulation can shed light on the biological underpinnings of anxiety disor-ders,providing important insights for developing personalized treatment strategies.This review emphasizes the need for in-depth studies on the mechanisms of A VP receptors,taking individual differences into account to advance precision medicine and improve the effec-tiveness of anxiety.关键词
后叶加压素/焦虑/神经机制/AVP受体/性别差异/社会环境Key words
vasopressin/anxiety/neural mechanisms/AVP receptors/gender differences/social environment分类
社会科学引用本文复制引用
胡琪东,吴奇,余凌峰,李红,雷怡..后叶加压素对焦虑的调节作用及其机制[J].四川师范大学学报（自然科学版）,2026,49(2):200-207,8.基金项目
国家自然科学基金面上项目(32271142)、教育部哲学社会科学研究重大课题攻关项目(21JZD063)和科技创新项目(20302022ZD0210900) （32271142）
