上海护理2026，Vol.26Issue(1)：25-31,7.DOI:10.3969/j.issn.1009-8399.2026.01.006
运动干预对2型糖尿病患者颈动脉内膜中层厚度影响的Meta分析
Meta-analysis of the Effects of Exercise Intervention on Carotid Intima Media Thickness in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To evaluate the effects of different forms and intensities of exercise intervention on carotid intima-media thickness(CIMT)in patients with type 2 diabetes mellitus(T2DM).Methods Randomized controlled trials on the effects of exercise intervention on CIMT in T2DM patients were searched in PubMed,Cochrane Library,Web of Science,CNKI,Wanfang Data,VIP and CBMdisc from their establishment to January 10,2024.Two investigators independently performed literature screening,quality evaluation and data extraction.The meta-analysis was conducted using RevMan 5.4 and Stata 16.The sources of heterogeneity were identified through subgroup analysis and sensitivity analysis.Results A total of 7 articles were included,involving 680 subjects.Meta-analysis revealed that CIMT was significantly reduced in T2DM patients receiving exercise intervention compared to the control group[MD=-0.06,95％CI(-0.09,-0.04),P<0.05].Subgroup analysis revealed that CIMT was significantly reduced in both the aerobic exercise group[MD=-0.10,95％CI(-0.12,-0.09)]and the aerobic+resistance exercise group[MD=-0.06,95％CI(-0.08,-0.03)]compared to the control group(P<0.05 for both),with a more significant effect on CIMT reduction in the aerobic exercise group(χ2=11.02,P<0.05);additionally,CIMT was significantly reduced in both the≤12-week intervention group[MD=-0.10,95％CI(-0.12,-0.07)]and the 12-month intervention group[MD=-0.04,95％CI(-0.08,-0.01)]compared to the control group(P<0.05 for both),with a more significant effect on CIMT reduction in the≤12-week intervention group(χ2=5.95,P<0.05).Egger's test showed no significant publication bias(t=0.58,P>0.05).Conclusion Exercise intervention significantly reduces CIMT in T2DM patients,with a superior effect on CIMT reduction in aerobic exercise,especially moderate-intensity continuous exercise.关键词
2型糖尿病/颈动脉内膜中层厚度/运动干预/运动形式/运动强度/Meta分析Key words
Type 2 diabetes mellitus/Carotid intima-media thickness/Exercise intervention/Exercise form/Exercise intensity/Meta-analysis分类
医药卫生引用本文复制引用
刘桂林,袁晓丹,麻晓君,张荣,方丹,顾莎莎..运动干预对2型糖尿病患者颈动脉内膜中层厚度影响的Meta分析[J].上海护理,2026,26(1):25-31,7.基金项目
2023年度预防医学课题面上项目(Ym2023048) （Ym2023048）
湖南省自然科学基金区域联合项目(2022JJ50027) （2022JJ50027）
2025年江苏省研究生实践创新计划(SJCX25_1104). （SJCX25_1104）
